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ZIRCONIUM DIOXIDE.

Insufficient Data CAS 1314-23-4 / OPACIFYING

Zirconium Dioxide is a white crystalline oxide primarily functioning as an opacifying agent in cosmetics. In its nanoparticle form, it demonstrates potential photoprotective and antioxidant benefits.

Summary

Opacifying agent Antioxidant Photoprotective agent UV absorber Pigment

Science

Mechanism of Action

As an opacifying agent, it reduces product transparency. Zirconia nanoparticles absorb UV radiation, offering photoprotection, and act as electron donors, exhibiting antioxidant activity by converting free radicals into stable products.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Demonstrated superior scavenging potential against hydroxyl radicals (IC50: 11.77 ± 0.15 μg/mL), exhibiting antioxidant activity.
  2. 02 Zirconia nanoparticles (50 nm) showed photoprotective activity in HaCaT cells, maintaining viability under UV irradiation.
  3. 03 Improved color stability of maxillofacial silicone elastomer at 1-3% concentrations after artificial aging.

Transparency

Dusting Analysis

Not commonly dusted

While Zirconium Dioxide is a white powder, the research does not indicate it is commonly 'dusted' in a way that compromises efficacy or product performance in cosmetic formulations.

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Known for exceptional thermal stability, high melting point, and chemical inertness, it resists degradation at high temperatures and corrosion.

Conflicts

  • Acids
  • Moisture

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not assessed Zirconium Dioxide. EWG Skin Deep assigns 'HIGH' use restrictions due to concerns about nano-scale absorption and potential for irritation from dust or prolonged contact.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

Despite promising in vitro benefits, the lack of direct skincare efficacy and comprehensive safety reviews, particularly for nano-forms, results in insufficient data for a definitive verdict.

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