Science
Mechanism of Action
This extract works by inhibiting inflammatory pathways (p38, ERK, Akt) and the caspase-3 apoptotic pathway. Its active phenylbutanoids, curcuminoids, and essential oils contribute to reducing inflammation, scavenging radicals, and supporting collagen production.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A 14% cream showed a strong trend for pain reduction in muscle pain and ankle sprain.
- 02 A 2-4% ethyl acetate fraction demonstrated photoprotective activity with SPF values of 11-17.
- 03 In vitro studies indicate potent anti-inflammatory (IC50 7.2-23.4 µg/mL) and anti-apoptotic (IC50 11.6 µg/mL) effects.
Transparency
Dusting Analysis
No data is available regarding the dusting characteristics or common dusting practices for this ingredient.
The Formula
Formulation
Stability
Extracts can be obtained using various organic solvents; green extraction with PEG 400 yields an oily extract suitable for direct formulation.
Safety
Safety Profile
While acute oral toxicity is low, previous studies have raised concerns about potential liver toxicity, making the overall safety profile not entirely clear. Minimal irritation was observed in fibroblast cells, and the oil exhibited low cytotoxicity below 10 µg/mL.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Zingiber Cassumunar Root Extract is a valuable ingredient, praised for its potent anti-inflammatory, antioxidant, and photoprotective benefits, coupled with broad skin compatibility.
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References
Sources