Science
Mechanism of Action
It protects skin fibroblasts from oxidative damage by preventing cell enlargement, reducing intracellular debris, and enhancing resilience against stressors. These benefits occur without inducing additional cell proliferation, maintaining youthful cellular function.
Research
Clinical Evidence
Medium confidence0.0018%
Key findings
- 01 Gerontomodulatory and youth-preserving effects of zeatin on human skin fibroblasts undergoing aging in vitro - PubMed
- 02 US20140271826A1 - Kinetin/zeatin topical formulation - Google Patents
Transparency
Dusting Analysis
No specific data suggests Zeatin is commonly dusted. Its complex solubility requires careful formulation to ensure active delivery and prevent underdosing.
The Formula
Formulation
Stability
Zeatin exhibits light and thermal sensitivity, requiring cold and light-protected storage. It is sparingly water-soluble but dissolves well in strong alkalis (pH 1.3-12.7) and certain organic solvents; solubilization is enhanced with liposome-forming and penetration-enhancing agents.
Conflicts
- light
- heat (in some complex media)
- solvents unsuitable for cosmetic formulations
Safety
Safety Profile
CIR status is 'not reviewed'. In vitro studies showed no toxicity or unwanted cell proliferation up to 200 microM, and it has low acute toxicity (LD50 2200 mg/kg in mice).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Zeatin is a highly promising anti-aging and antioxidant ingredient, demonstrating youth-preserving effects on skin cells with a good safety profile.
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