Science
Mechanism of Action
It inhibits neuronal electrical signals to relax facial muscles, diminishing wrinkles. Additionally, it boosts pro-collagen I synthesis and upregulates LOX, strengthening the skin's extracellular matrix.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 ResearchGate, NIH
- 02 MDPI
Transparency
Dusting Analysis
Effective concentrations for wrinkle reduction (0.006%) and collagen stimulation (0.01%) exceed the CIR's recommended maximum safe use concentration of 0.0022% for cosmetic preparations.
The Formula
Formulation
Stability
Specific optimal pH for stability in cosmetic formulations is not explicitly stated; a plant cell culture was maintained at pH 6.5.
Synergies
- Acetyl Hexapeptide-8
Conflicts
- Fragrant components (e.g., Limonene, Citronellol, Geranyl Acetate) may irritate sensitive skin, requiring careful formulation.
- Potential for heavy metals and pesticide residues in botanical ingredients.
Safety
Safety Profile
The CIR panel noted a lack of toxicity data, but GRAS status for food mitigates concerns. Formulators must ensure non-sensitizing products due to naturally occurring terpenes.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While studies show promising anti-aging and collagen-boosting effects, the effective concentrations exceed the CIR's recommended maximum safe use limit, warranting cautious formulation.
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