Science
Mechanism of Action
This extract neutralizes free radicals, inhibits elastase to maintain skin elasticity, and reduces tyrosinase activity to diminish hyperpigmentation. It also calms inflammation, supports collagen production, and exhibits antimicrobial action against Gram-positive bacteria.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Anti-aging effect by inhibiting anti-tyrosinase (~54%) and anti-elastase (~98%) at 1 mg/mL.
- 02 Anti-inflammatory capacity, inhibiting Nitric Oxide production up to 35.25% at 5.00-75.00 µg/mL.
- 03 Significant antioxidant activity (IC50 = 42.5 µg/mL for ethyl acetate extract).
- 04 Significant anti-inflammatory activity (IC50 = 26.6 µg/mL for ethyl acetate extract).
Transparency
Dusting Analysis
No data suggests this ingredient is commonly dusted. Its benefits are supported by various studies, indicating genuine efficacy.
The Formula
Formulation
Stability
Grape stem extracts are typically prepared with hydroethanolic solvents and stability studies suggest light and temperature influence long-term stability. High ethanol concentrations for extraction are discouraged due to protein denaturation risk.
Safety
Safety Profile
The CIR Expert Panel found Vitis vinifera (grape)-derived ingredients, including stem extract, safe as used in cosmetics. It has a very low allergy risk, though a patch test is recommended for known grape allergies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This multifaceted botanical extract offers significant antioxidant, anti-inflammatory, and anti-aging benefits, making it a valuable addition for most skin types.
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