Science
Mechanism of Action
This extract acts as an antioxidant by scavenging radicals and reducing activity, while its anti-inflammatory effects stem from inhibiting pro-inflammatory cytokines and nitric oxide production. It provides anti-aging benefits through cytoprotection against UVB damage and by downregulating MMPs and inhibiting collagenase/elastase enzymes.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A comprehensive review of ethnomedicinal approaches, phytochemical analysis, and pharmacological potential of Vitex trifolia L.
- 02 Antioxidant, Antielastase, Anticollagenase, and UVB-Protective Effects of Vitex trifolia
- 03 Effects of Vitex trifolia L. leaf extracts and phytoconstituents on cytokine production in human U937 macrophages
Transparency
Dusting Analysis
Effective concentrations observed in studies span a wide range, from very low to higher percentages, making it less likely to be commonly dusted. Further research is needed to determine an optimal percentage for consistent performance.
The Formula
Formulation
Safety
Safety Profile
The extract was non-toxic up to 0.01% in HaCaT keratinocytes, but cytotoxicity was observed in U937 macrophages at concentrations as low as 0.00012-0.00047% depending on extraction. Dermal toxicity and pregnancy safety are not determined.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Vitex Trifolia Fruit Extract presents a valuable profile with a broad range of in vitro benefits, though more human clinical data and safety assessments, especially regarding cytotoxicity at very low concentrations, would solidify its widespread recommendation.
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