Science
Mechanism of Action
This extract inhibits pro-inflammatory cytokines like TNF-α and IL-1β, alongside nitric oxide production, and scavenges reactive oxygen species. It protects the extracellular matrix by inhibiting elastase and collagenase, reducing MMP expression, and decreasing melanogenesis.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Aqueous extracts inhibited NO production in RAW 264.7 cells at 0.25 g/L without toxicity.
- 02 Maceration ethanol leaf extract inhibited TNF-α and IL-1β production in U937 macrophages (IC50 29.2-43.6 μg/mL).
- 03 Demonstrated strong antioxidant activity, selective enzyme inhibition (anti-elastase, anti-collagenase), and suppressed UVB-induced MMP expression.
- 04 Ethanol leaf extract showed significant wound healing activity, increasing collagenation and contraction rates.
- 05 Leaf oil and abietatriene reduced melanogenesis, suggesting potential for hyperpigmentation treatment.
Transparency
Dusting Analysis
No specific data on dusting practices for this ingredient was available in the provided research.
The Formula
Formulation
Stability
Ethanolic and aqueous extracts contain beneficial compounds like flavonoids. A syrup formulation with 11% propylene glycol demonstrated good stability and preserved vitexicarpin levels.
Safety
Safety Profile
A broad safety margin was observed in HaCaT cells. However, one review indicates a need for more detailed study on the clinical relevance and safety of plant extracts.
Your Skin
Skin Compatibility
Our Assessment
Verdict
This botanical extract offers a broad spectrum of skin benefits including anti-inflammatory, antioxidant, and anti-aging effects, making it a valuable ingredient despite limited specific human topical clinical data.
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References
Sources