Science
Mechanism of Action
This extract combats free radicals and reduces inflammation by regulating immune mediators and alleviating key cellular pathways like MAPKs, STAT-1, and NF-κB. It also exhibits anti-photoaging effects by boosting procollagen type I, elastin, and TGF-β1 expression, while diminishing MMP-1 production.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Oral ingestion inhibited atopic dermatitis-like lesions in mice, reducing mast cells and inflammatory cytokines.
- 02 In vitro, it suppressed MMP-1 production by 90% in UVB-exposed human dermal fibroblasts.
- 03 In UVB-irradiated hairless mice, it suppressed wrinkle formation and skin thickness by promoting elastin (118%) and procollagen type I (156%) expression.
Transparency
Dusting Analysis
There is no information to suggest that Vigna Angularis Seed Extract is commonly dusted in formulations.
The Formula
Formulation
Stability
The extract's proteins have lowest solubility around pH 4.0. Hot water and ethanol are common extraction solvents, and activity was observed at pH 8.0 in an elastase inhibition assay.
Safety
Safety Profile
Generally considered safe for topical cosmetic use, with an excellent safety profile. It is non-allergenic and suitable for various skin types, with mild reactions being rare. Patch testing is always recommended.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Vigna Angularis Seed Extract is a valuable ingredient due to its potent anti-aging, anti-inflammatory, and skin-protecting benefits, coupled with an excellent safety profile for all skin types.
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