Science
Mechanism of Action
Its anti-inflammatory action is attributed to compounds like ursolic acid and quercetin, inhibiting pro-inflammatory cytokines. Antioxidant activity stems from phenolic compounds and vitamins, while antimicrobial effects, particularly against S. aureus, involve inhibiting Sortase A and biofilm formation.
Research
Clinical Evidence
Low confidenceN/A
Key findings
- 01 In vitro studies demonstrated that concentrations between 100 µg/mL and 500 µg/mL inhibited Staphylococcus aureus Sortase A activity and biofilm formation. Specifically, 500 µg/mL ethanolic and acetonic extracts showed over 90% inhibition of SpA expression in S. aureus ATCC 29213 cells.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
CIR reports insufficient data for definitive topical safety; pregnant or breastfeeding individuals are advised to avoid use. Rare contact dermatitis has been observed, primarily in those handling fresh bark.
Your Skin
Skin Compatibility
Our Assessment
Verdict
While promising in vitro for its anti-inflammatory and antimicrobial potential, the lack of comprehensive safety and in-vivo efficacy data warrants a cautious approach in precision skincare formulations.
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References
Sources