Science
Mechanism of Action
It delivers bioactive phytochemicals, including phenolic acids and flavonoids, to provide potent antioxidant defense against free radicals and oxidative stress. Additionally, it calms inflammation by suppressing pro-inflammatory cytokine signaling and helps regulate sebum production by inhibiting 5α-reductase.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 Reduced reactive oxygen species (ROS) in H2O2-stimulated human skin fibroblasts and protected against H2O2-induced cytotoxicity, maintaining cell viability.
- 02 Increased HEK-293 and HaCaT cell proliferation by up to 39% and 30% respectively, and a two-fold increase in cell migration rate. An ointment containing the extract accelerated wound healing to 9 days compared to 13 days for untreated wounds.
- 03 In vitro, a 5 mg/mL ethanol extract suppressed TNF-α by 50.8% and IL-1β by 99.7% in LPS-induced human whole blood after 24 hours.
Transparency
Dusting Analysis
The Formula
Formulation
Safety
Safety Profile
Generally considered safe for cosmetic use, it typically does not irritate the skin and is well-tolerated. While non-comedogenic, patch testing is advisable for individuals with sensitive skin or known allergies.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Urtica Dioica Root Extract is a valuable ingredient, offering broad benefits from antioxidant protection and anti-inflammatory action to sebum regulation and wound healing, with a favorable safety profile.
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