Science
Mechanism of Action
This synthetic signal peptide, a subfragment of type I collagen propeptide, enhances dermal remodeling. It stimulates collagen (types I, III, IV), fibronectin, and glycosaminoglycan production, inhibits collagenase, and helps regulate hyaluronic acid, improving skin texture and reducing wrinkles.
Research
Clinical Evidence
High confidence0.005%
Key findings
- 01 Significantly reduced facial wrinkles and fine lines in a 12-week clinical trial.
- 02 Reduced crow's feet fold depth by 18%, thickness by 37%, and skin firmness by 21% when applied twice daily for 28 days.
- 03 Achieved 25-34% overall wrinkle reduction over a 28-day period.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Stable within a pH range of 5-7. The palmitoyl modification enhances oil solubility and skin penetration; however, some formulations may require surfactants for optimal water dispersion.
Safety
Safety Profile
Safety assessments for this ingredient are primarily derived from comprehensive studies on its widely recognized analogue, Palmitoyl Pentapeptide-4, which is deemed safe as used by the CIR Expert Panel. It exhibits low irritancy and was well tolerated in clinical applications up to 0.012%.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A highly effective signal peptide, drawing data from its well-researched analogue Palmitoyl Pentapeptide-4, for significant anti-aging benefits and skin texture improvement across all skin types.
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