Science
Mechanism of Action
Operating as an anti-inflammatory agent, Undecyl Rhamnoside (specifically the APRC11 variant) precisely modulates the expression of inflammatory mediators within human keratinocytes. It effectively down-regulates P. acnes-induced cytokines, including IL-1α, IL-8, and MMP-9, while simultaneously enhancing levels of the anti-inflammatory cytokine IL-1RA, thereby mitigating cutaneous inflammation.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A study involving normal human keratinocytes stimulated by P. acnes showed that Undecyl Rhamnoside (APRC11) significantly down-regulated the expression of inflammatory molecules (IL-1α, IL-8, and MMP-9) and up-regulated IL-1RA levels. This anti-inflammatory action was comparable to Zinc Gluconate, indicating its potential for inflammatory acne management.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Rhamnolipids, a broader class encompassing Undecyl Rhamnoside derivatives, exhibit peak emulsifying activity around pH 8 when evaluated across a pH range of 3 to 9. The overall stability of rhamnoside derivatives is generally pH-dependent.
Safety
Safety Profile
No specific safety assessments from major regulatory bodies such as CIR, SCCS, or FDA were found for Undecyl Rhamnoside, and it is not listed in the CIR status report.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Undecyl Rhamnoside presents as a valuable ingredient for managing inflammatory skin conditions, particularly acne, by precisely targeting inflammatory pathways, making it suitable for oily and sensitive skin types.
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References
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