Science
Mechanism of Action
This extract operates via several key pathways: it notably inhibits pro-inflammatory cytokines such as IL-6 and the transcription factor NF-κB, thereby calming skin inflammation. Its antioxidant capacity involves scavenging free radicals and mitigating oxidative stress. Crucially, it enhances the skin's natural DNA repair mechanisms, particularly following UV exposure, and exhibits antimicrobial properties to help safeguard against infections. Furthermore, it contributes to skin soothing, reduction of redness and itching, and supports overall skin vitality.
Research
Clinical Evidence
High confidence0.5%
Key findings
- 01 A water extract (C-Med-100) at 0.5% was clinically demonstrated to significantly reduce skin cell death from UV exposure and enhance DNA repair processes in human skin organ cultures.
- 02 A dermo-cosmetic spray containing Uncaria Tomentosa Extract was well-tolerated and efficacious in relieving pain, itching, and improving physical signs associated with chronic inflammatory skin diseases and dermatological procedures.
Transparency
Dusting Analysis
There is no available data to suggest that Uncaria Tomentosa Extract is commonly dusted or requires specific dusting thresholds for efficacy or safety.
The Formula
Formulation
Stability
Specific stability notes are not provided in the available research, but its water solubility suggests potential for aqueous formulations.
Synergies
- Exhibits enhanced soothing and anti-inflammatory effects when combined with ingredients such as Rhealba® Oat plantlets extract, as demonstrated in dermo-cosmetic applications.
Safety
Safety Profile
Generally considered safe for topical application and well-tolerated, with demonstrated low toxicity. Individuals with known allergies to the Rubiaceae plant family or specific Uncaria species may experience localized allergic reactions. SkinSAFE identifies it as 'Irritant Free', 'Dye Free', 'SLS Free', and 'Paraben Free'. Caution is advised for internal use by pregnant/nursing women, young children, or those on certain medications; however, these precautions are not specifically tied to topical application.
Your Skin
Skin Compatibility
Our Assessment
Verdict
A valuable botanical ingredient, Uncaria Tomentosa Extract offers potent DNA repair, anti-inflammatory, and antioxidant benefits, making it highly effective for promoting skin resilience and overall health across various skin types.
Related
Similar Ingredients
Finding similar ingredients…
Keep exploring
From ingredients to everyday care.
Sensitive skin ↗
Start with comfort, product choices and the questions to ask.
Barrier support ↗
Understand moisture, lipids and the limits of ingredient claims.
Ingredient names help you read a label. They do not establish how a finished product will perform. Explore The Garden.