Science
Mechanism of Action
This extract operates through a complex blend of phytoconstituents including oxindole and indole alkaloids, glycosides, and proanthocyanidins. Its anti-inflammatory action effectively calms sensitive skin and mitigates irritation. As a robust antioxidant, it neutralizes free radicals, thereby reducing visible signs of aging such as inflammation, fine lines, wrinkles, and hyperpigmentation. Furthermore, it supports intrinsic DNA repair mechanisms, providing defense against UV-induced cellular damage, and exhibits antimicrobial properties to help prevent microbial proliferation associated with conditions like acne and eczema.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 A 0.5% concentration of a water extract (C-Med-100) was observed to reduce skin cell death from UV exposure and enhance DNA repair in human skin organ cultures.
- 02 A dermo-cosmetic spray containing Uncaria tomentosa demonstrated good tolerability and efficacy in alleviating cutaneous pain symptoms linked to inflammatory skin conditions (e.g., atopic dermatitis, psoriasis, hand eczema) and post-dermatological procedures.
- 03 Commercial formulations, such as a Brazilian herbarium gel cream, have utilized Uncaria tomentosa bark extract at a concentration equivalent to 5%.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
An aqueous ammonia extract was noted to be adjusted to a neutral pH using acetic acid during preparation, indicating potential preference for neutral pH environments for stability or efficacy.
Synergies
- When combined with Rhealba® Oat plantlets extract in a dermo-cosmetic spray, it demonstrated enhanced relief for pain associated with inflammatory skin conditions.
Safety
Safety Profile
Formal cosmetic safety reviews by CIR, SCCS, or FDA are currently unavailable. While specific side effects for topical application are not definitively established, studies on a dermo-cosmetic spray incorporating this extract reported good to excellent dermatological tolerance. It has been designated 'Irritant Free' by SkinSAFE. Caution regarding oral intake during pregnancy, for individuals with autoimmune diseases, kidney disease, or Parkinson's disease, and with specific medications has been noted, though these do not directly apply to topical use where comprehensive safety data remains limited.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Uncaria Tomentosa Bark Extract is a valuable multi-functional ingredient known for its DNA repair enhancement, anti-inflammatory, and antioxidant properties, making it beneficial for protecting and soothing a wide range of skin types.
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References
Sources