Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

TYROSYL HISTIDINE HCL.

Valuable CAS 94111-42-9 / ANTIOXIDANT

Tyrosyl Histidine HCL is a dipeptide formed from L-Tyrosine and L-Histidine, designed for enhanced skin delivery. It supports skin health through pH regulation, barrier reinforcement, and moisturization. This ingredient also contributes to antioxidant defense and influences processes like wound healing and melanin synthesis.

Summary

pH Balancer Skin Barrier Support Humectant Antioxidant Wound Healing UV Protection (Precursor) Melanin Synthesis Regulation

Science

Mechanism of Action

This dipeptide delivers the benefits of its constituent amino acids. L-Histidine acts as a proton buffer, maintaining optimal skin pH crucial for barrier function, and a metal ion chelator, mitigating oxidative degradation. It also functions as a humectant, promoting skin hydration and conditioning. Furthermore, histidine is a precursor to histamine, which supports wound healing by mediating angiogenesis and macrophage activity, and to urocanate, offering some intrinsic UV protection. L-Tyrosine serves as a precursor in the melanin synthesis pathway. The dipeptide structure enhances solubility and potentially improves cellular uptake compared to its free amino acid forms.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

No data available in the provided research regarding 'dusting' properties or thresholds for Tyrosyl Histidine HCL.

The Formula

Formulation

Solubility
Water
Optimal pH 5 – 7.4
0 7 14

Stability

The histidine component provides optimal buffering efficacy within a pH range of 5.5-6.5, though its effective buffering capacity can extend from pH 5.0 to 6.9, and it is also utilized effectively at pH 7.4 for protein stabilization. The dipeptide form exhibits enhanced solubility compared to free tyrosine. Care should be taken to avoid storing high concentrations in liquid formulations in stainless steel tanks at elevated temperatures, which may lead to coloration and aggregation.

Conflicts

  • High concentrations in liquid formulations with stainless steel tanks at elevated temperatures

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While Tyrosyl Histidine HCL itself has not undergone specific CIR or SCCS review, its component L-Histidine is recognized as Generally Recognized As Safe (GRAS) by the FDA. Related compounds like Histidine HCl are considered safe food additives and have been deemed non-irritating at typical cosmetic concentrations by the CIR Expert Panel, suggesting a low risk profile for this dipeptide.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Tyrosyl Histidine HCL is a valuable multi-functional ingredient, leveraging the broad benefits of its amino acid components for hydration, barrier integrity, antioxidant defense, and influencing skin repair and pigment processes.

Related

Similar Ingredients

Finding similar ingredients…