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TUSSILAGO FARFARA FLOWER/LEAF EXTRACT.

Questionable CAS 84625-50-3 / SKIN CONDITIONING

Derived from the Coltsfoot plant, Tussilago Farfara Flower/Leaf Extract is a multi-functional skincare ingredient recognized for its robust soothing, anti-irritant, and antioxidant benefits. It actively conditions the skin, mitigates oxidative stress, and supports regenerative processes such as barrier repair and collagen production.

Summary

Antioxidant Anti-inflammatory Soothing Skin Conditioning Anti-irritant Barrier Support Collagen Booster Anti-glycation Wound Healing Skin Rejuvenating

Science

Mechanism of Action

Tussilago Farfara Flower/Leaf Extract exerts its effects through a rich composition of active compounds, including flavonoids like apigenin, luteolin, kaempferol 3-0-rutinoside, and hyperoside. These constituents provide significant anti-inflammatory and antioxidant activity, thereby reducing oxidative stress and irritation. Furthermore, the extract contributes to skin conditioning, supports the repair of the skin barrier, enhances collagen synthesis, offers anti-glycation benefits, and aids in wound healing, collectively promoting overall skin rejuvenation.

Research

Clinical Evidence

Medium confidence
Effective range 5–10%
Optimal

N/A

Key findings

  1. 01 Concentrations of 5-10% of a 20% extract (equivalent to 1-2% active extract) have demonstrated excellent soothing, anti-irritant, and antioxidant properties in skincare applications.
  2. 02 A general use level of 5-10% is widely recommended for skincare products, with some formulations suggesting usage up to 2% for external cosmetic purposes.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For optimal stability, store the extract in a cool, dark environment, protected from heat, direct sunlight, and exposure to air.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Tussilago Farfara naturally contains tumorigenic pyrrolizidine alkaloids (PAs), such as senecionine and senkirkine, which are primarily associated with liver toxicity upon internal consumption. The German government has restricted coltsfoot sales due to these PAs, although PA-free clonal plants have been developed. For topical skincare, PA concentrations are generally considered too low to be clinically significant, and no human toxicity cases have been linked to recommended topical dosages. PAs are water-soluble, suggesting that water-based extracts may contain higher levels than oil-based ones. The ingredient is typically non-irritating for external use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

Despite its potent soothing, anti-inflammatory, and antioxidant benefits for skin, the unreviewed safety status by CIR and the presence of pyrrolizidine alkaloids warrant extreme caution in formulation, ideally requiring verified PA-free sourcing for a precision skincare brand.

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