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TRISODIUM HEDTA.

Valuable CAS 139-89-9 / CHELATING

Trisodium HEDTA is a highly effective chelating agent that inactivates polyvalent metal ions, thereby enhancing the stability of cosmetic formulations and improving the performance of cleansing products. It also possesses a recognized capacity to facilitate the dermal absorption of other topical ingredients.

Summary

chelating penetration-enhancing

Science

Mechanism of Action

This ingredient functions as a sequestrant, forming stable complexes with metal ions such as calcium, magnesium, and iron. By sequestering these ions, Trisodium HEDTA prevents their involvement in reactions that can lead to product deterioration, rancidity, and fragrance degradation. On the skin, it aids in preventing the undesirable deposition of hard water mineral ions and has been identified as a penetration enhancer, potentially increasing the uptake of co-formulated compounds.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 10.5 – 11
0 7 14

Stability

Trisodium HEDTA exhibits high water solubility, achieving maximal levels (≥40% w/v) within an ideal pH range of 10.5–11.0. It demonstrates limited solubility in most organic solvents. Its chelating efficacy for trivalent iron is optimal between pH 7 and 10. As it is slightly hygroscopic, protection from moisture is advised. Aqueous solutions should be stored in alkali-free containers to maintain stability.

Safety

Safety Profile

CIR Status
Safe as used
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that Trisodium HEDTA is safe for use in cosmetic formulations, reporting it to be non-irritating and non-sensitizing at concentrations typically employed. Studies indicate no carcinogenic potential. Skin absorption of related EDTA ingredients is minimal. While typical concentrations for EDTA are below 2%, Trisodium HEDTA is generally used at even lower percentages. Formulators should be cognizant of its recognized role as a penetration enhancer, which could impact the absorption kinetics of other active ingredients. Related EDTA salts are FDA-approved food preservatives, and Trisodium HEDTA is listed as a Food Contact Substance by the FDA.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Trisodium HEDTA is a valuable ingredient for maintaining cosmetic product integrity and enhancing cleansing performance, with an additional capacity to improve the absorption of other active ingredients, making it suitable for all skin types.

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