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TRISODIUM ETHYLENEDIAMINE DISUCCINATE.

Valuable CAS 20846-91-7 / 178949-82-1 / CHELATING

Trisodium Ethylenediamine Disuccinate is a precision chelating agent that plays a vital role in preserving the integrity and performance of skincare formulations. By binding to detrimental metal ions, it prevents undesirable reactions, ensuring product stability and enhancing the efficacy of other active ingredients.

Summary

Chelating Agent Formulation Stabilizer Preservative Booster Cleansing Performance Enhancer

Science

Mechanism of Action

As a chelating agent, Trisodium Ethylenediamine Disuccinate selectively complexes various metal ions, including calcium, iron, copper, and magnesium. This targeted sequestration prevents these ions from catalyzing reactions that can lead to product degradation, oxidation, or changes in aesthetics such as color, odor, and texture. This action stabilizes the formulation, improves the performance of cleansing surfactants in hard water, and bolsters the efficiency of preservative systems, allowing active components to function optimally.

Research

Clinical Evidence

High confidence
Effective range 0.64–29.41%
Optimal

N/A

Key findings

  1. 01 The CIR Expert Panel (2023) evaluated this ingredient in over 199 cosmetic formulations, concluding its safety for cosmetic use with low irritation, sensitization, and toxicity risks.
  2. 02 A Human Repeated Insult Patch Test (HRIPT) conducted on 111 subjects, using an aqueous solution under occlusive conditions, observed no irritation or sensitization.
  3. 03 Repeat patch tests on 12 subjects, with 24-hour applications of an aqueous solution under occlusive conditions, demonstrated no observed irritation.

Transparency

Dusting Analysis

Not commonly dusted

Trisodium Ethylenediamine Disuccinate's primary function is to stabilize formulations by chelating metal ions, rather than delivering direct, dose-dependent skin benefits. Therefore, it is not an ingredient for which 'dusting' to achieve specific skin effects is relevant.

The Formula

Formulation

Solubility
Water
Optimal pH 6.5 – 7.5
0 7 14

Stability

Its inherent chelating capabilities are crucial for maintaining product stability, preventing metal ion-induced degradation, oxidation, and undesirable changes in aesthetic properties like color, odor, or texture.

Synergies

  • Enhances the performance of cleansing surfactants, particularly in hard water environments.
  • Fortifies and extends the efficacy of preservative systems.
  • Ensures optimal stability and function of other active ingredients within a formulation.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.64%
Sensitization risk Low

Deemed safe for cosmetic use by the CIR Expert Panel (2023) at concentrations up to 0.64%, with minimal risks for irritation, sensitization, and toxicity. It is approved under European Cosmetics Regulation, listed by EU COSING as a chelating agent, and rated as a low-hazard ingredient by EWG. While generally well-tolerated, patch testing is advisable for individuals with particularly sensitive skin. One *in vitro* mammalian chromosomal aberration assay indicated positive mutation results, though this did not affect its overall safety assessment for cosmetic use. The FDA has also approved its use as a food contact substance in specific applications at concentrations up to 0.31%.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Trisodium Ethylenediamine Disuccinate is a valuable ingredient, critical for enhancing the stability, efficacy, and overall longevity of cosmetic formulations by expertly managing metal ion interference, with a strong safety profile across diverse skin types.

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