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TRISODIUM EDTA.

Valuable CAS 150-38-9 / CHELATING

Trisodium EDTA is a highly effective chelating agent integrated into skincare formulations to enhance product stability and efficacy. It precisely binds to various metal ions, preventing their detrimental reactions within the formula. This action ensures consistent product quality, protects delicate ingredients, and extends shelf life.

Summary

chelating stabilizer

Science

Mechanism of Action

As a chelating agent, Trisodium EDTA operates by sequestering metal ions, such as calcium, magnesium, and iron, rendering them inactive. This neutralization process is crucial for preventing metal ion-induced product deterioration, maintaining formula clarity, preserving fragrance integrity, and guarding against oxidative rancidity. Furthermore, it helps prevent mineral deposits from forming on the skin and hair, and its calcium-chelating property can subtly enhance the penetration of co-formulated active ingredients.

Research

Clinical Evidence

High confidence
Effective range 0.05–2%
Optimal

0.5%

Key findings

  1. 01 Trisodium EDTA is widely recognized for its robust chelating capabilities, essential for stabilizing cosmetic formulations against degradation caused by trace metal ions. Industry practice and safety assessments confirm its efficacy and safety at concentrations typically below 2%, with many formulations successfully utilizing it at or below 0.5% for optimal stability and minimal irritation risk.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Trisodium EDTA is water-soluble and maintains its efficacy across a broad pH range. As an edetate salt, it exhibits superior stability compared to its free acid form. However, it is mildly hygroscopic and vulnerable to moisture, necessitating storage in cool, dry, well-sealed containers away from temperatures exceeding 120°C.

Synergies

  • Enhances the stability and efficacy of other active ingredients by neutralizing interfering metal ions.

Conflicts

  • Due to its function as a penetration enhancer, particularly by chelating calcium, formulators should exercise caution when combining Trisodium EDTA with ingredients whose safety profile relies on limited dermal absorption.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
2%
Sensitization risk Low

The CIR Expert Panel has concluded that Trisodium EDTA, alongside other EDTA compounds, is safe for use in cosmetics and personal care products at typical concentrations. It has not been identified as a dermal irritant, sensitizer, or carcinogen, and its absorption through the skin is minimal. Its use is also generally permitted by European regulatory bodies like the SCCS.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Trisodium EDTA is a valuable and well-tolerated ingredient that significantly enhances cosmetic product stability and integrity by effectively neutralizing problematic metal ions within formulations.

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