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TRISODIUM DICARBOXYMETHYL ALANINATE.

Valuable CAS 164462-16-2 / CHELATING

Trisodium Dicarboxymethyl Alaninate is a powerful chelating agent crucial for maintaining the integrity and efficacy of cosmetic formulations. By binding to detrimental metal ions, it safeguards products against degradation and discoloration, ensuring consistent performance of other active ingredients.

Summary

Chelating Formulation stabilization Preservative efficacy boosting Water softening Discoloration prevention

Science

Mechanism of Action

This ingredient functions by sequestering metal ions, thereby preventing their interference with cosmetic components. This chelating action is pivotal for stabilizing formulations, inhibiting metal-induced discoloration, and bolstering preservative effectiveness. Furthermore, it aids in water softening, optimizing the performance of surfactants and other ingredients.

Research

Clinical Evidence

Medium confidence
Effective range 0.1–1%
Optimal

N/A

Key findings

  1. 01 Commonly incorporated into cosmetic products within the 0.1% to 1.0% concentration range, it is generally recognized as safe and effective for its intended purpose.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH 2 – 14
0 7 14

Stability

Aqueous solutions exhibit exceptional chemical stability across a broad pH range of 2 to 14, even under high temperatures exceeding 200°C when pressurized. It maintains stability in both acidic and alkaline conditions under standard storage, though extreme environments may lead to decomposition. For solid preparations, it resists oxidizing agents like perborates and percarbonates but is incompatible with oxidizing acids or sodium hypochlorite. Optimal integration involves mixing into the water phase, avoiding temperatures above 80°C; its typical solution pH is between 8.5 and 11.5.

Synergies

  • Preservatives (enhanced efficacy)
  • Surfactants (improved performance due to water softening)

Conflicts

  • Oxidizing acids
  • Sodium hypochlorite

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
1%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has determined it safe for use in rinse-off products, with a maximum concentration of 1% but notes limited data for leave-on applications. The EU Cosmetics Regulation permits its use within specified concentration limits. While generally considered safe in diluted cosmetic forms, high concentrations may act as a mild irritant, and direct eye contact can cause irritation. A preliminary patch test is advised for individuals with sensitive skin. The FDA indirectly regulates it as GRAS for indirect food contact.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Trisodium Dicarboxymethyl Alaninate is a valuable formulation enhancer, stabilizing products and boosting ingredient efficacy through its chelating action, with a strong safety profile at typical cosmetic concentrations.

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