Science
Mechanism of Action
Its primary action involves absorbing harmful UV radiation and converting it into less damaging thermal energy, thereby protecting both the skin and product integrity. Concurrently, it neutralizes free radicals, mitigating oxidative damage at the cellular level. Furthermore, it aids in preserving skin hydration and suppleness, contributing to enhanced elasticity.
Research
Clinical Evidence
High confidence0.05%
Key findings
- 01 Clinical evaluations and human repeated insult patch tests at 0.05% consistently demonstrated low irritation potential and no significant sensitization across 104 subjects.
- 02 Research indicates its effective free radical scavenging capabilities, leading to reduced oxidative stress in topically treated skin cells.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
This ingredient is highly water-soluble (500 g/L at 20.5°C). Its UV absorption properties are enhanced by the deprotonation of its hydroxyl groups at pH levels above 6.2. It is prone to hydrolysis in acidic environments (pH < 4), necessitating formulation within a buffered pH range, ideally between 7.4 and 8.0 (e.g., using 10 mM Tris-HCl). Strong oxidizing agents will degrade the compound.
Conflicts
- strong oxidizers
- formulations with pH below 4
Safety
Safety Profile
The Cosmetic Ingredient Review (CIR) Expert Panel has deemed TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE safe for use in cosmetic applications, with a maximum concentration of 0.05% for leave-on and rinse-off products, and up to 0.005% in eye lotions. It has consistently shown low irritation potential in various tests, including rabbit eye irritation and guinea pig maximization tests, and is not considered a sensitizer. Furthermore, it is non-comedogenic (comedogenic rating: 0). Regulatory bodies, such as the European Cosmetics Regulation, permit its use but recommend dermatological testing for products containing this ingredient.
Your Skin
Skin Compatibility
Our Assessment
Verdict
TRIS(TETRAMETHYLHYDROXYPIPERIDINOL)CITRATE is a valuable multi-tasking ingredient, offering robust UV protection, significant antioxidant benefits, and enhanced skin hydration, all within a safe and non-irritating profile suitable for most skin types.
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