Science
Mechanism of Action
Operating as a vegan, skin-identical recombinant collagen type III (SH-Polypeptide-69), TRIPEPTIDE-69 signals the skin to activate its endogenous repair mechanisms. It robustly stimulates the synthesis of crucial collagen types I and III, while simultaneously inhibiting key enzymes like collagenase and metalloproteinases (MMPs) responsible for the breakdown of the extracellular matrix (ECM) and dermal-epidermal junction (DEJ). This dual action preserves and strengthens the skin's structural integrity, leading to a visible reduction in wrinkle appearance.
Research
Clinical Evidence
High confidenceN/A
Key findings
- 01 Extensive in vitro and ex vivo studies demonstrate TRIPEPTIDE-69's efficacy in inhibiting collagenase activity, stimulating the synthesis of collagen types I and III, and preventing overall collagen breakdown. It has also been shown to improve the extracellular matrix (ECM) and enhance the dermal-epidermal junction (DEJ), contributing to improved skin texture, elasticity, and firmness.
Transparency
Dusting Analysis
No available data suggests that TRIPEPTIDE-69 is frequently incorporated into products at sub-efficacious concentrations merely for marketing purposes.
The Formula
Formulation
Stability
Specific formulation stability data, including optimal pH and solubility details, are not detailed in the available research.
Safety
Safety Profile
While SH-Polypeptide-69's specific Cosmetic Ingredient Review (CIR), SCCS, or FDA safety status has not yet been published, general assessments by CIR for groups of tissue-derived proteins and peptides often classify them as safe for cosmetic applications, with no specific restrictions in the EU.
Your Skin
Skin Compatibility
Our Assessment
Verdict
TRIPEPTIDE-69 is a highly valuable and innovative peptide that powerfully targets multiple aspects of skin aging by boosting collagen synthesis and safeguarding structural integrity, suitable for all skin types.
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References
Sources