Get a Free 5ml Mini Now Free 5ml Mini With Every Order of The Mantle
Moumoujus

TRIPEPTIDE-49 OLIGOPEPTIDE-91 DIPEPTIDE-19 SH-POLYPEPTIDE-1.

Questionable / SKIN CONDITIONING

This intricate blend of peptides functions as a potent cell-communicating and skin-conditioning agent. It is engineered to activate the skin's intrinsic repair mechanisms, aiming to enhance regeneration, restore elasticity, and diminish visible signs of aging.

Summary

Skin-identical ingredient Cell-communicating ingredient Skin conditioning Promotes collagen synthesis Enhances elastin production Supports skin repair and regeneration Reduces appearance of wrinkles and fine lines Improves skin elasticity and firmness Boosts cellular proliferation Enhances skin barrier function Provides long-term moisturization Accelerates wound healing Improves skin tone

Science

Mechanism of Action

This sophisticated peptide complex operates by mimicking key natural growth factors within the skin. SH-Polypeptide-1, an analog of Basic Fibroblast Growth Factor (bFGF), stimulates fibroblasts to produce collagen and elastin, improving skin elasticity and smoothing wrinkles. It also supports blood vessel development and keratinocyte growth factor expression. SH-Oligopeptide-1, an Epidermal Growth Factor (EGF) analog, promotes advanced skin repair, accelerates self-regeneration, enhances blood vessel formation, and boosts the synthesis of extracellular matrix components such as collagen, elastin, and hyaluronic acid, leading to improved barrier function and reduced scarring. SH-Polypeptide-19, mimicking Transforming Growth Factor-alpha (TGF-α), accelerates keratinocyte generation and migration, aiding wound healing, improving skin tone, and stimulating nerve ending renewal for enhanced skin nutrition and reduced expression lines. Collectively, these peptides signal cellular processes to rejuvenate and repair the skin.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Direct clinical studies on the comprehensive TRIPEPTIDE-49 OLIGOPEPTIDE-91 DIPEPTIDE-19 SH-POLYPEPTIDE-1 blend are currently unavailable. While sh-Oligopeptide-1, a component, is authorized for cosmetic use in various concentrations, its long-term safety data is incomplete, and some related clinical findings have faced scientific scrutiny.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

As water-soluble peptides, these larger recombinant molecules may benefit from advanced delivery systems like liposomes or PLGA-coated nanoparticles to optimize stability, dermal penetration, and overall efficacy. The precise optimal pH range for this specific complex is not documented, though similar collagen tripeptides demonstrate resilience to enzymatic degradation.

Safety

Safety Profile

CIR Status
Safe with restrictions
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has broadly deemed various peptides safe for cosmetic use under current practices. However, this complex includes growth factor analogs (SH-Polypeptide-1, SH-Oligopeptide-1, SH-Polypeptide-19) that mimic natural growth factors (bFGF, EGF, TGF-α). Overexpression or dysregulation of these natural factors is scientifically linked to tumorigenesis. Consequently, significant caution is advised when using products containing such growth factor-mimetic peptides, as their long-term safety risks in cosmetic applications remain largely unknown. There is no specific SCCS or FDA safety status for this exact blend.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

This complex offers significant potential for advanced skin regeneration and anti-aging benefits through its growth factor-mimicking peptides, yet substantial unknowns regarding long-term safety and potential tumorigenesis warrant extreme caution.

Related

Similar Ingredients

Finding similar ingredients…