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Moumoujus

TRIPEPTIDE-38.

Valuable CAS - / SKIN CONDITIONING

TRIPEPTIDE-38, commercially known as Matrixyl Synthe'6, is a sophisticated biomimetic peptide engineered to deeply revitalize the skin. It precisely targets the dermal matrix to significantly reduce the appearance of fine lines and wrinkles, simultaneously enhancing skin firmness and elasticity for a smoother, more youthful complexion.

Summary

skin-restoring humectant anti-aging anti-wrinkle elasticity-boosting firming hydrating skin-repairing barrier-strengthening

Science

Mechanism of Action

This advanced synthetic peptide functions by mimicking matrikines, which are natural signaling molecules crucial for tissue repair and regeneration. TRIPEPTIDE-38 stimulates skin cells to augment the synthesis of six essential components of the extracellular matrix (ECM) and the dermal-epidermal junction: Collagen I, Collagen III, Collagen IV, Fibronectin, Hyaluronic acid, and Laminin-5. This multi-faceted action works to plump skin, diminish the depth of wrinkles, enhance overall skin repair processes, and improve both skin tightness and elasticity. Additionally, it promotes the production of aquaporins, optimizing cellular water retention and distribution, and strengthens genes involved in lipid barrier function, thereby bolstering skin protection and minimizing transepidermal moisture loss. It further regulates Matrix Metalloproteinase (MMP) activity, which is vital for maintaining the structural integrity of the skin.

Research

Clinical Evidence

High confidence
Effective range 0.0005–2%
Optimal

2%

Key findings

  1. 01 In a study utilizing a 2% concentration of Matrixyl Synthe'6 (containing Palmitoyl Tripeptide-38), participants observed a significant decrease in signs of aging, ranging from 31% to 100%, over two months, with initial visible wrinkle smoothing occurring in as little as one week.
  2. 02 Topical application at 1% (w/w) as part of an active complex in an anti-wrinkle cream demonstrated measurable anti-wrinkle effects over a 12-week period in women aged 30-50.
  3. 03 A study involving women over 40 with visible photoaging showed improvements in skin roughness and tone after 56 days of using a vitamin C serum formulated with 5 ppm (0.0005%) palmitoyl tripeptide-38.

Transparency

Dusting Analysis

Not commonly dusted

As a potent signaling peptide, TRIPEPTIDE-38 demonstrates efficacy at very low concentrations, with clinical benefits observed from 0.0005% up to 2%. Its precise mechanism of action suggests that higher concentrations beyond these clinically validated ranges may not yield proportionally greater benefits and could indicate formulation inefficiency rather than enhanced performance.

The Formula

Formulation

Solubility
Both
Optimal pH 3 – 6
0 7 14

Stability

TRIPEPTIDE-38 maintains stability within a pH range of 3.0 to 6.0; formulations with a pH below 3.5 should be explicitly avoided to prevent degradation. It is commonly incorporated as a clear, odorless, water-soluble liquid, often blended with glycerin and water. The palmitoyl modification is crucial for enhancing its lipid solubility and subsequent dermal penetration.

Conflicts

  • Highly acidic formulas (pH < 3.5)
  • Copper peptides (can reduce performance when layered)
  • Over-exfoliating acids in the same routine

Safety

Safety Profile

CIR Status
Insufficient data
Sensitization risk Low

Palmitoyl Tripeptide-38 is listed within the FDA's Voluntary Cosmetic Registration Program (VCRP). While the Cosmetic Ingredient Review (CIR) has noted 'insufficient data' and referenced some animal and occupational studies showing irritation at high doses or equivocal irritation, it is generally regarded as a safe cosmetic active ingredient. It is described as chemically pure, biodegradable, non-toxic, and has a short biological lifespan due to proteolytic enzyme degradation. Safety Data Sheets indicate it is 'not irritant' to the skin, and SkinSAFE classifies it as 'Irritant Free', 'Fragrance Free', and 'Paraben Free'.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

TRIPEPTIDE-38 is a valuable peptide for anti-aging formulations, demonstrating significant efficacy in reducing wrinkle depth, improving skin firmness, and enhancing overall skin quality through its multi-targeted action on the extracellular matrix.

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