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TRIPEPTIDE-34.

Valuable CAS - / SKIN CONDITIONING

TRIPEPTIDE-34, most notably as its copper complex GHK-Cu, is a powerful signaling peptide engineered to activate the skin's inherent repair and regenerative pathways. It works to significantly enhance skin structure, improving both appearance and resilience against visible signs of aging and environmental damage.

Skin-Restoring Anti-Aging Collagen Boosting Elastin Boosting Wound Healing Skin Repair Antioxidant Anti-Inflammatory Skin Firming Skin Elasticity Improvement Hyperpigmentation Reduction Photoprotection Skin Clarity Improvement

Science

TRIPEPTIDE-34 functions as a carrier peptide, initiating the skin's endogenous repair mechanisms. It robustly stimulates the proliferation of dermal fibroblasts and elevates the production of vascular endothelial growth factor. This promotes skin and tissue regeneration, encourages angiogenesis, and accelerates collagen synthesis, all critical for the restoration of healthy skin structure. Tripeptides engage with specific cellular receptors to trigger vital cell migration, proliferation, and differentiation. Specifically, GHK-Cu tightens loose skin, repairs protective skin barrier proteins, and improves firmness, elasticity, and clarity. It effectively reduces the appearance of fine lines and wrinkle depth, smooths rough skin texture, and diminishes photodamage, mottled hyperpigmentation, and skin lesions. Furthermore, it stimulates wound healing, provides protection against UV radiation, and actively reduces inflammation and free radical damage. GHK-Cu modulates metalloproteinase and anti-protease activity, supports regeneration through the synthesis of collagen, glycosaminoglycans, and decorin, and activates the ubiquitin proteasome system (UPS).


Research

High confidence
Effective range N/A
Optimal

N/A


Transparency

Not commonly dusted

The Formula

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

GHK-Cu, a form of copper tripeptide, is highly sensitive to degradation by carboxypeptidase enzymes, which may be present in wound serum. Formulating it with other potentially problematic ingredients could elevate the risk of irritation or issues with aesthetic stability.


Safety

CIR Status
Not reviewed
Sensitization risk Low

TRIPEPTIDE-34 itself has not undergone direct review by the CIR Expert Panel. However, the Panel has concluded that related ingredients, including Tripeptide-1, Hexapeptide-12, their metal salts, fatty acyl derivatives, and Palmitoyl Tetrapeptide-7 (which encompasses Copper Tripeptide-1), are safe for cosmetic use. Typical use concentrations for these related peptides are generally less than 10 ppm. It is important to note that this safety assessment is applicable only to ingredients with specific, defined peptide sequences. No SCCS opinion or specific FDA status for topical TRIPEPTIDE-34 was found in the available data.


Your Skin

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Valuable

TRIPEPTIDE-34, particularly as GHK-Cu, is a highly valuable ingredient for its extensive skin regenerative, anti-aging, and restorative capabilities, consistently demonstrating significant improvements in overall skin structure and appearance.


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