Science
Mechanism of Action
This peptide functions by targeting and reinforcing the dermal-epidermal junction (DEJ), the crucial connection between the epidermis and dermis. It stimulates the production of key anchoring components, including collagen VII, laminin-5, and fibronectin. This action improves the skin's mechanical properties, providing increased resistance, reduced sagging, and an overall smoother, more resilient skin surface.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
No data within the provided research suggests that TRIPEPTIDE-31 is commonly used at sub-efficacious percentages for marketing purposes.
The Formula
Formulation
Stability
TRIPEPTIDE-31 (acetate) is described as a water-soluble crystal in its raw form. However, for maximum solubility in aqueous buffers, it is recommended to first dissolve it in an organic solvent, such as ethanol, before diluting it into the aqueous phase. A 1:3 solution of ethanol:PBS at pH 7.2 has demonstrated a solubility of 0.25 mg/ml. No specific optimal pH range for broader stability has been identified.
Safety
Safety Profile
TRIPEPTIDE-31 (Caprooyl Tetrapeptide-3) is characterized by an exceptional safety profile, deemed non-invasive, and suitable for sensitive skin. It is recognized by the FDA with UNII LZI0HJ3K2R. SkinSAFE rates it as Teen SAFE, Lip SAFE, Baby SAFE, Eyelid SAFE, Common Preservative Free, and Irritant Free. No explicit maximum safe concentration has been established by regulatory bodies like CIR or SCCS in the provided data.
Your Skin
Skin Compatibility
Our Assessment
Verdict
TRIPEPTIDE-31 is a valuable anti-aging peptide that visibly improves skin firmness, elasticity, and reduces wrinkles by strengthening the dermal-epidermal junction, supported by quantitative efficacy data and an excellent safety profile for all skin types.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources