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Moumoujus

TRIPEPTIDE-12.

Valuable CAS - / SKIN CONDITIONING

TRIPEPTIDE-12 is a bioactive, cell-communicating peptide recognized for its skin-identical properties and regenerative potential. It actively supports the skin's natural repair mechanisms, stimulating collagen synthesis and enhancing barrier function for improved structural integrity and resilience.

Summary

skin-identical ingredient cell-communicating ingredient anti-aging skin regeneration collagen booster skin barrier support wound healing

Science

Mechanism of Action

TRIPEPTIDE-12, as a member of the tripeptide class, interacts with specific cellular receptors to initiate vital processes such as cell migration, proliferation, and differentiation. It significantly promotes tissue repair and accelerates collagen synthesis, crucial for restoring skin structure and increasing density. This peptide also helps to modulate inflammatory responses, mitigate oxidative stress, and enhance the function of fibroblasts and keratinocytes. Furthermore, it can integrate with lipid components in the stratum corneum to strengthen the skin barrier and improve water retention.

Research

Clinical Evidence

Medium confidence
Effective range 0.0004–0.001%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

As an active ingredient, TRIPEPTIDE-12 is typically incorporated at precise, low concentrations to elicit its biological effects, rather than being used at high, non-functional percentages.

The Formula

Formulation

Solubility
Both
Optimal pH 5 – 6
0 7 14

Stability

For optimal stability and prolonged shelf life in solution, peptides like TRIPEPTIDE-12 are best formulated in sterile buffers within a pH range of approximately 5.0-6.0. While basic tripeptides are generally water-soluble, lipid-modified derivatives show enhanced affinity for oil components, suggesting versatility in formulation.

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.001%
Sensitization risk Low

The Cosmetic Ingredient Review (CIR) Expert Panel has concluded that TRIPEPTIDE-12 and its related derivatives, including Tripeptide-1 and Hexapeptide-12, are safe for use in cosmetics. Typical concentrations in products are generally less than 0.001% (10 ppm), though some data indicate use up to 0.003% (30 ppm). A formulation reportedly containing 0.01% (100 ppm) of Palmitoyl Tripeptide-12 was found to be non-irritating to rabbit eyes, suggesting a wide safety margin for this class of peptides.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

TRIPEPTIDE-12 is a valuable cell-communicating peptide that supports skin regeneration, collagen synthesis, and barrier function, making it beneficial for anti-aging and overall skin health with a low irritation risk across all skin types.

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