Science
Mechanism of Action
TRIPEPTIDE-11 functions as a synthetic signal peptide, driving the proliferation of keratinocytes to increase cellular density and accelerate skin regeneration. It notably enhances the synthesis of syndecan-1, a crucial proteoglycan, to strengthen epidermal cohesion and improve the structural integrity of the dermo-epidermal junction (DEJ). Furthermore, it stimulates collagen production within dermal fibroblasts and refines skin texture by acting on surface proteins.
Research
Clinical Evidence
High confidence3%
Key findings
- 01 Clinical studies over 8 weeks demonstrated increased epidermal cohesion, stimulating the synthesis of syndecan-1 and collagen XVII. This led to improved skin firmness and elasticity, alongside enhanced epidermal coordination for a visibly more even and clearer complexion.
- 02 In primary human keratinocytes, this concentration was shown to elevate levels of SYND1 and collagen XVII, key components for skin structure.
- 03 Application resulted in noticeably thicker and firmer skin, exhibiting superior efficacy when compared to placebo formulations.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
To maintain optimal stability, TRIPEPTIDE-11 should be stored away from light, moisture, and heat. Refrigeration is recommended for long-term preservation.
Safety
Safety Profile
TRIPEPTIDE-11 is generally very well tolerated by the epidermis. Health risks are considered minimal due to its typical use in very small percentages within final formulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
TRIPEPTIDE-11 is a valuable peptide that significantly strengthens skin structure, enhances firmness and elasticity, and promotes a clearer, more even complexion.
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References
Sources