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Moumoujus

TRIMETHYLBICYCLO-3-HEPTEN-2-ONE.

Questionable CAS 18309-32-5 / PERFUMING

TRIMETHYLBICYCLO-3-HEPTEN-2-ONE, commonly referred to as Verbenone, is a naturally occurring bicyclic monoterpene ketone. Its primary application in cosmetic formulations is as a fragrance component, imparting a distinct aromatic profile.

Summary

fragrance ingredient

Science

Mechanism of Action

While Verbenone is widely recognized for its ecological role as an anti-aggregation pheromone for bark beetle species, its specific mechanism of action or targeted benefits on human skin for cosmetic purposes remains largely undetailed in current research. Although some studies allude to potential antimicrobial and anti-inflammatory properties, a precise mechanistic pathway for these effects in human skincare has not been explicitly established.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

Verbenone demonstrates good stability under normal storage conditions. For optimal preservation, it should be stored in a cool, well-ventilated area, protected from direct sunlight, and in a tightly sealed container. Elevated temperatures should be avoided as they can increase its volatility and potentially lead to explosive atmospheres.

Conflicts

  • strong acids
  • alkalis
  • oxidizing agents

Safety

Safety Profile

CIR Status
Safe with restrictions
Max tested
8%
Sensitization risk Moderate

TRIMETHYLBICYCLO-3-HEPTEN-2-ONE is registered under REACH in the European Economic Area. GHS classifications indicate it is harmful if swallowed (H302), causes skin irritation (H315), and may cause an allergic skin reaction (H317), in addition to causing serious eye irritation (H319). The Research Institute for Fragrance Materials (RIFM) recommends usage levels up to 8.0000% in fragrance concentrates, noting its potential for sensitization via skin contact. While the FDA lists it as a flavoring agent or adjuvant, a specific CIR or SCCS review for its cosmetic use is not readily available. These classifications highlight a notable risk for irritation and sensitization, particularly for individuals with reactive skin.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Moderate
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

TRIMETHYLBICYCLO-3-HEPTEN-2-ONE functions primarily as a fragrance component in skincare, but its lack of established direct skin benefits and potential for irritation and allergic sensitization warrant careful consideration in formulations.

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