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Moumoujus

TRIFOLIUM PRATENSE LEAF EXTRACT.

Valuable CAS 85085-25-2 / ANTIOXIDANT, SKIN CONDITIONING

Derived from the red clover plant, Trifolium Pratense Leaf Extract is a multi-functional botanical celebrated for its phytoestrogen content, which delivers comprehensive anti-aging benefits to the skin. It also demonstrates efficacy in improving scalp health and reducing hair loss, making it a versatile ingredient for both skin and hair formulations.

Summary

Antioxidant Skin-soothing Astringent Humectant Anti-aging Firming Collagen Stimulating Hair Growth Promoting

Science

Mechanism of Action

This extract functions through several pathways: it is rich in phytoestrogens, notably isoflavones like genistein and biochanin A, which mimic estrogen's effects to stimulate collagen synthesis, enhancing skin elasticity and firmness, thereby mitigating the appearance of fine lines. Potent antioxidant flavonoids and isoflavones within the extract provide cellular protection against environmental oxidative stress from factors such as UV radiation and pollution. Its tannin content imparts astringent properties, aiding in the removal of dead skin cells, controlling sebum production, and minimizing pore appearance. Furthermore, it calms irritated skin with anti-inflammatory effects and may boost hyaluronic acid production for improved hydration. Specifically, the isoflavone Biochanin A inhibits 5-alpha-reductase, a key enzyme involved in premature hair loss by reducing dihydrotestosterone (DHT).

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Significantly improved markers of skin aging, including increased skin thickness, enhanced keratinization, improved vascularity, and greater collagen and elastic fiber density over 14 weeks in ovariectomized rats. This suggests a reduction in skin aging associated with estrogen deprivation.
  2. 02 Reduced markers of skin aging induced by estrogen deprivation in ovariectomized rats over 14 weeks. Histological examination revealed well-organized skin architecture with normal epidermal thickness, regular keratinization, and robust vascularity, collagen, and elastic fiber development.
  3. 03 Topical application to the scalp for 4 months resulted in a 13% increase in the anagen (hair growth) phase and a 29% decrease in the telogen (hair loss) phase in 30 men, compared to a placebo group.

Transparency

Dusting Analysis

Not commonly dusted

Current research data does not provide sufficient information to determine if Trifolium Pratense Leaf Extract is commonly 'dusted' or at what concentration it becomes ineffective. The observed efficacy in studies varies by the concentration of active components (isoflavones) and the extract percentage, particularly for hair growth.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

This extract maintains stability under cool, dry storage conditions, away from light. Exposure to excessive heat or moisture can lead to degradation and a reduction in potency.

Conflicts

  • strong acids
  • strong bases
  • oxidizing agents
  • open flames
  • high temperatures

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

Generally considered safe with a low potential for irritation or skin sensitivities, and it is approved by regulatory bodies such as the EU Cosmetic Regulation. The FDA lists 'CLOVER, EXTRACT (TRIFOLIUM SPP.)'. However, it is not advised for use on compromised or wounded skin to prevent potential allergic reactions, and a patch test is recommended before widespread application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Low

Our Assessment

Verdict

Valuable

Trifolium Pratense Leaf Extract is a valuable botanical ingredient, offering diverse benefits from anti-aging skin rejuvenation and hydration to effective hair loss prevention, supported by mechanistic understanding and promising clinical data.

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