Science
Mechanism of Action
Functioning primarily as an antioxidizing agent, Trifluoromethylphenethyl Mesalazine efficiently neutralizes free radicals, evidenced by an in vitro IC50 of 14.7 mM. It exhibits anti-melanogenic properties by inhibiting melanin production and anti-wrinkle effects by reducing UV-induced production of matrix metalloproteinase-1 (MMP-1) and interleukin-6 (IL-6) in cultured human skin fibroblasts. This action helps maintain the skin's good condition, improving its appearance and texture for a softer, smoother, and more supple feel.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The modification of mesalazine to include a trifluoromethylphenethyl group is noted to enhance its stability and efficacy in topical applications.
Safety
Safety Profile
No specific CIR or SCCS reviews for Trifluoromethylphenethyl Mesalazine were found. Its use in cosmetics falls under general FDA regulations, including the Modernization of Cosmetics Regulation Act of 2022 (MoCRA), which requires responsible persons to ensure and maintain records supporting adequate safety substantiation. This synthetic ingredient undergoes purification and testing for efficacy and safety prior to its incorporation into cosmetic formulations.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Trifluoromethylphenethyl Mesalazine is a valuable synthetic ingredient demonstrating significant antioxidative, anti-melanogenic, and anti-wrinkle efficacy, making it well-suited for advanced anti-aging skincare formulations.
Related
Similar Ingredients
Finding similar ingredients…
References
Sources