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Moumoujus

TRICHOSANTHES KIRILOWII SEED EXTRACT.

Valuable / HUMECTANT, SKIN CONDITIONING, SKIN PROTECTING

Derived from the seeds of Trichosanthes kirilowii, this extract presents a multi-faceted profile for skin health. It is engineered to significantly accelerate cellular renewal and wound healing processes, alongside delivering robust antioxidant and anti-inflammatory benefits.

Summary

Wound Healing Cell Proliferation Booster Antioxidant Anti-aging Anti-inflammatory

Science

Mechanism of Action

The extract promotes keratinocyte proliferation through the activation of the ERK1/2 signaling pathway, which subsequently upregulates mRNA expression of critical transcription factors like c-fos and c-jun (AP-1 family) and cell cycle regulators known as cyclins. Furthermore, it enhances the expression of growth factors such as CTGF and VEGF, which are instrumental in stimulating angiogenesis and tissue repair. The seed oil component independently contributes to improved oxidative stress tolerance and anti-aging efficacy.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

Current research data does not indicate common dusting practices or specific concentration thresholds associated with potential dusting for this ingredient in topical applications.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Trichosanthes kirilowii seed oil contains conjugated linolenic acids, which are susceptible to oxidation and polymerization into viscous compounds under typical temperatures. Cold pressing during extraction is recommended to yield an oil with enhanced quality and antioxidant stability.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

A comprehensive toxicological safety assessment of Semen Trichosanthis (derived from these seeds) for oral administration revealed no genotoxic, acute, subchronic, or teratogenic risks under tested conditions. Acute oral administration resulted in no mortality or toxicity (LD50 > 20 g/kg BW), and subchronic exposure established a No-Observed-Adverse-Effect-Level (NOAEL) of ≥ 5 g/kg BW. While promising, these findings pertain to oral intake; specific topical safety reviews by cosmetic regulatory bodies are currently pending.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

TRICHOSANTHES KIRILOWII SEED EXTRACT is a valuable asset, exhibiting significant in vitro efficacy in boosting skin regeneration and providing broad protective properties, rendering it highly suitable for reparative and age-defying skincare applications.

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