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TRICHOSANTHES KIRILOWII FRUIT POWDER.

Valuable / ABRASIVE, FRAGRANCE, SKIN PROTECTING

Trichosanthes Kirilowii Fruit Powder is a botanical ingredient recognized for its potent anti-inflammatory and antioxidant properties. It actively supports skin regeneration and wound healing while providing soothing and moisturizing benefits.

Summary

antioxidant anti-inflammatory skin protecting moisturizing soothing wound healing skin regeneration anti-aging

Science

Mechanism of Action

This ingredient functions by stimulating keratinocyte proliferation, a crucial step in skin repair, through the activation of ERK1/2 phosphorylation. This activation upregulates the expression of key cellular regulators and growth factors, including c-fos, c-jun (AP-1 transcription factors), cyclins, Connective Tissue Growth Factor (CTGF), and Vascular Endothelial Growth Factor (VEGF), collectively fostering skin renewal and angiogenesis. Additionally, it mitigates oxidative stress and reduces inflammatory responses, contributing to a protected and calm complexion.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Significantly improved keratinocyte proliferation by 145.38% and enhanced wound closure through re-epithelialization by 238.2%. This effect was mediated by promoting ERK1/2 phosphorylation and inducing the expression of c-fos, c-jun, cyclins, CTGF, and VEGF.
  2. 02 Effectively alleviated proinflammatory cytokines, chemokines, and eotaxin in stimulated BEAS-2B cells. No significant cytotoxic effects were observed at concentrations up to 200 μg/mL.

Transparency

Dusting Analysis

Not commonly dusted

No data suggests that TRICHOSANTHES KIRILOWII FRUIT POWDER is commonly 'dusted' in cosmetic formulations. However, extract powders may require carrier substances for stability and form.

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

Extract powders may necessitate the use of carrier substances like dextrin or microcrystalline cellulose to ensure stability and proper powder formation. Both water-soluble and ethanol fractions have been investigated.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

TRICHOSANTHES KIRILOWII FRUIT POWDER is currently listed under 'No Reported Uses' in the FDA's Voluntary Cosmetics Reporting Program, indicating no immediate safety concerns requiring further CIR review. Toxicological evaluations of Trichosanthes kirilowii seeds (Semen Trichosanthis) have demonstrated a generally low toxicity, with no detectable genotoxic, acute, subchronic, or teratogenic risks under tested conditions.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Trichosanthes Kirilowii Fruit Powder is a valuable botanical ingredient, offering significant regenerative, anti-inflammatory, and antioxidant benefits to promote wound healing and overall skin vitality across all skin types.

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