Science
Mechanism of Action
This extract offers powerful antioxidant and anti-inflammatory actions that improve skin texture and reduce irritation, gently soothing redness and strengthening the skin barrier against external stressors. It contributes to skin hydration and softness through its moisturizing properties. Crucially, it promotes skin regeneration and wound healing by stimulating keratinocyte proliferation, achieved via activation of ERK1/2 phosphorylation and an increase in mRNA expression of key proteins such as c-fos, c-jun, CTGF, and VEGF.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 An in vitro wound-healing assay demonstrated significant efficacy at 100 µg/mL, improving keratinocyte proliferation by 145.38% and accelerating wound closure by 238.2%. This was linked to enhanced ERK1/2 phosphorylation and increased mRNA expression of c-fos, c-jun, CTGF, and VEGF.
- 02 While not directly reflective of skin application efficacy, a study using 0-100 μg/mL orally administered extract in an ovalbumin-sensitized mouse model showed alleviation of proinflammatory cytokines, chemokines, and eotaxins in airway inflammation, suggesting broader anti-inflammatory potential.
Transparency
Dusting Analysis
No data available to suggest this ingredient is commonly 'dusted' at ineffective concentrations.
The Formula
Formulation
Safety
Safety Profile
No specific safety assessments by CIR or SCCS were found. Its use falls under general cosmetic ingredient regulations, with no specific FDA approval status beyond general cosmetic use identified. Incidecoder suggests low irritancy.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Trichosanthes Kirilowii Fruit Extract is a valuable ingredient, particularly for promoting skin regeneration and soothing irritated skin, making it highly beneficial for compromised or sensitive complexions.
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References
Sources