Science
Mechanism of Action
This extract functions primarily as an antioxidant by scavenging superoxide anion radicals, attributed to its rich content of flavalignans, flavan-3-ols, and flavonoids. It also demonstrates anti-inflammatory effects and can act as an anticholinesterase. Furthermore, it exhibits virucidal activity, interfering with early stages of viral replication, and provides neuroprotective benefits against oxidative stress, contributing to overall skin health and resilience.
Research
Clinical Evidence
Medium confidenceN/A
Key findings
- 01 In vitro studies show significant antioxidant activity, with an ethanolic extract achieving an IC50 of 9.17-76.42 mcg/ml in DPPH assays. Specific components, such as cinchonain Ic (2.5 µM) and Id (2.3 µM), demonstrated high radical scavenging activity.
- 02 At concentrations of 10-100 µg/mL, the extract significantly attenuated pro-oxidant induced toxicity and exerted neuroprotective effects in rat hippocampal slices, suggesting protection against oxidative damage.
- 03 Virucidal activity was observed at concentrations of 12.5–100 µg/ml, interfering with the initial replication phase of poliovirus and bovine herpesvirus, and showing anti-herpetic activity against HSV.
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The active components of Trichilia Catigua Extract can be isolated using diverse solvents, including hydroalcoholic, aqueous, hexane, and chloroform, indicating its versatility for incorporation into both water- and oil-based formulations.
Safety
Safety Profile
Trichilia Catigua Extract currently lacks formal safety review by organizations like CIR, SCCS, or FDA for cosmetic use. While no specific GHS classification or oral/dermal/inhalation toxicity data is readily available, platforms like SkinSAFE classify products containing this extract as 'Teen SAFE', 'Lip SAFE', 'Baby SAFE', 'Eyelid SAFE', and 'Irritant Free', suggesting a generally favorable safety profile in finished products. A study on microemulsions with the extract also assessed toxicity and comedogenicity in rabbits.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Trichilia Catigua Extract is a valuable botanical ingredient, offering robust antioxidant, anti-inflammatory, and skin-conditioning benefits, with promising virucidal activity for targeted concerns.
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