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Moumoujus

TRIBULUS TERRESTRIS ROOT EXTRACT.

Valuable CAS 90131-68-3 / SKIN CONDITIONING

Tribulus Terrestris Root Extract is a botanical active rich in steroidal saponins and flavonoids, offering a multi-faceted approach to skin health. It is recognized for its anti-inflammatory, antioxidant, and antimicrobial properties, making it beneficial for various skin concerns including acne and irritation. This extract also supports skin elasticity and aims to enhance overall skin vitality.

Summary

Anti-inflammatory Antioxidant Antimicrobial Skin Conditioning Collagen Support Hyperpigmentation Management

Science

Mechanism of Action

This root extract contains bioactive compounds like steroidal saponins, flavonoids, and alkaloids. It reduces inflammation by decreasing inflammatory acne lesions and modulating pro-inflammatory cytokines such as IL-1α and IL-8, alongside keratin 16. In atopic dermatitis, it mitigates inflammation by regulating calcium channels (inhibiting Orai-1 and activating TRPV3) and stabilizing mast cells. As a potent antioxidant, it combats oxidative stress. It further exhibits antibacterial effects against pathogens like Staphylococcus aureus and Escherichia coli, and antifungal activity by compromising fungal cell membrane integrity. Additionally, it may influence tyrosinase activity for hyperpigmentation management, promote collagen synthesis for improved elasticity, and enhance microcirculation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An 8-week, double-blinded, randomized, controlled trial demonstrated a significant reduction in both non-inflammatory and inflammatory acne lesions in subjects with mild-to-moderate acne compared to placebo. This suggests efficacy for T. terrestris L. containing formulations in acne management.
  2. 02 Topical application of 1% T. terrestris L. fruit extract, when combined with 0.1% hydrocortisone, significantly alleviated key symptoms of atopic dermatitis, including erythema, edema, epidermal hyperplasia, and reduced transepidermal water loss (TEWL), thereby improving overall symptom scores.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The composition and biological activity of Tribulus Terrestris extract can vary significantly based on its origin, extraction method, and the specific plant part used (root, leaf, or fruit). Careful selection and standardization of raw materials are crucial for ensuring consistent product performance and efficacy.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

No specific regulatory status (CIR, SCCS, FDA) for topical 'Tribulus Terrestris Root Extract' has been established. An 8-week clinical trial involving a T. terrestris L. containing herbal extract reported only mild adverse events (e.g., burning sensation) in 6 out of 60 cases, indicating a generally good safety profile for topical use in that specific formulation. However, it's noted that an in vitro study reported a genotoxic effect of T. terrestris L. fruit extract at high concentrations in cultured human lymphocytes, which requires consideration, although this was not observed in topical applications. Instances of liver injury linked to orally administered Tribulus in grazing animals are not convincingly associated with human topical applications.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Tribulus Terrestris Root Extract is a valuable botanical ingredient, offering diverse benefits including anti-inflammatory, antioxidant, and antimicrobial actions, making it suitable for targeted treatments for acne, sensitive, and irritated skin while supporting overall skin health.

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