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Moumoujus

TRIBULUS TERRESTRIS FRUIT/STEM EXTRACT.

Insufficient Data CAS 90131-68-3 / SKIN CONDITIONING

Tribulus Terrestris Fruit/Stem Extract is a botanical active known for its diverse biological actions, including anti-inflammatory, antioxidant, and antimicrobial properties. It demonstrates potential in enhancing skin barrier function and modulating tyrosinase activity.

Summary

skin conditioning anti-inflammatory antioxidant antimicrobial skin barrier support tyrosinase inhibitor

Science

Mechanism of Action

This extract operates by suppressing inflammatory mediators such as cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2), while also stabilizing mast cells to reduce degranulation. It modulates cellular calcium channels, inhibiting Orai-1 to reduce T cell activation and activating TRPV3 to promote skin barrier repair and alleviate pruritus. Enriched with bioactive compounds like steroidal saponins, flavonoids, and alkaloids, it offers antioxidant benefits and exhibits antimicrobial efficacy against pathogens like *Staphylococcus epidermidis* and *Candida albicans*.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

1%

Key findings

  1. 01 A 2017 study demonstrated that 1% *Tribulus terrestris* fruit extract, when combined with 0.1% hydrocortisone, significantly mitigated symptoms of oxazolone-induced atopic dermatitis in mice. Observed effects included a reduction in skin erythema, edema, epidermal hyperplasia, and transepidermal water loss (TEWL). The extract effectively inhibited skin inflammation, decreased inflammatory cell infiltration, regulated Orai-1 and TRPV3 channels, and stabilized mast cells without inducing cytotoxicity.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Synergies

  • Clinical data suggests potential synergistic effects when combined with 0.1% hydrocortisone for managing symptoms of atopic dermatitis.

Safety

Safety Profile

CIR Status
Not reviewed
Pregnancy
Caution
Sensitization risk Low

While generally regarded as safe at recommended doses, systemic use may lead to hormonal imbalances, mood fluctuations, or menstrual irregularities in some individuals. Rare instances of allergic reactions, including skin rashes or itching, have been reported topically. This ingredient is not an FDA-approved drug. Pregnant or breastfeeding individuals should avoid its use due to a lack of safety data. Individuals with hormone-sensitive conditions (e.g., prostate conditions, hormone-sensitive cancers) should consult a healthcare provider before use.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While exhibiting promising anti-inflammatory, barrier-supportive, and antimicrobial properties in animal studies, further human topical clinical data and safety reviews are required to establish its efficacy and safety for broad cosmetic use.

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