Science
Mechanism of Action
This botanical extract demonstrates anti-inflammatory action by soothing irritated skin, reducing redness, and attenuating key inflammatory cytokines such as IL-6 and TNF-α. Its efficacy extends to modulating calcium channels, specifically inhibiting Orai-1 activity and enhancing TRPV3, alongside decreasing mast cell activation. Furthermore, it exhibits significant antioxidant capabilities, bolstering cellular defense against oxidative stress, neutralizing free radicals, and supporting mitochondrial membrane potential to combat premature aging. Preliminary evidence also suggests roles in improving microcirculation, antibacterial activity, and tyrosinase regulation.
Research
Clinical Evidence
Medium confidenceWhile a human optimal percentage is not definitively established, a 1% concentration was observed to be effective in mouse models for reducing inflammation and improving skin barrier function.
Key findings
- 01 Topical application in mice with oxazolone-induced atopic dermatitis significantly improved skin inflammation, reduced transepidermal water loss (TEWL), and decreased symptom scores by modulating calcium channels (inhibiting Orai-1, increasing TRPV3) and mast cell activation.
- 02 An 8-week human clinical trial involving 60 individuals with mild-to-moderate acne observed a significant reduction in both inflammatory and non-inflammatory acne lesions with a topical preparation containing Tribulus Terrestris. This correlated with decreased expression of inflammatory cytokines (IL-1α, IL-8) and keratin 16, though mild adverse events like a burning sensation were reported in 6 cases.
Transparency
Dusting Analysis
Information regarding 'dusting' or common sub-clinical concentrations for Tribulus Terrestris Fruit Extract is not available in the provided research data.
The Formula
Formulation
Stability
The composition and biological activity of Tribulus Terrestris Fruit Extract can vary significantly depending on factors such as the specific plant parts used, extraction methods, growth conditions, and harvesting period. For consistent cosmetic formulation, the use of standardized extracts is crucial.
Safety
Safety Profile
While generally considered safe for topical use, some individuals have reported mild adverse events such as a burning sensation or allergic reactions, including skin rashes and itching. Due to a lack of comprehensive safety data, it is advised for pregnant or breastfeeding individuals to avoid its use. Individuals with hormone-sensitive conditions should consult a healthcare provider before use, as the extract is associated with hormonal effects when ingested. This ingredient has not been reviewed by the Cosmetic Ingredient Review (CIR).
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tribulus Terrestris Fruit Extract is a valuable botanical ingredient, demonstrating promising anti-inflammatory and antioxidant properties for skin conditioning and managing conditions like acne and atopic dermatitis, though precise topical concentrations require further human study.
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