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Moumoujus

TRANSGENIC RICE RH-OLIGOPEPTIDE-2.

Questionable / SKIN CONDITIONING

TRANSGENIC RICE RH-OLIGOPEPTIDE-2 is a biotechnologically produced peptide, mimicking the body's natural Insulin-like Growth Factor-1 (IGF-1). It functions as a potent signaling molecule to stimulate skin regeneration, enhance elasticity, and promote comprehensive skin rejuvenation. This advanced ingredient is designed for precision anti-aging formulations.

Summary

Skin Regeneration Elasticity Improvement Collagen Synthesis Cell Renewal Tissue Repair Anti-aging Effects Hydration Enhancement Cell-communicating Ingredient Skin-restoring

Science

Mechanism of Action

This synthetic single-chain polypeptide acts as an analog to naturally occurring IGF-1, initiating critical cellular processes. It stimulates fibroblast and keratinocyte proliferation, promoting the renewal of skin cells and boosting the production of essential collagen types (I, III, and IV). Furthermore, it aids in synthesizing other vital extracellular matrix components like fibronectin and glycosaminoglycans, working to repair and reconstruct the dermal extracellular matrix and epidermal-dermal junction. By activating the AKT pathway and enhancing hyaluronic acid biosynthesis, rh-Oligopeptide-2 contributes to reduced wrinkle depth, improved skin appearance, supported tissue repair, wound healing gene expression, and revitalization of aged cells through enhanced microcirculation.

Research

Clinical Evidence

Insufficient-data confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

For optimal stability, TRANSGENIC RICE RH-OLIGOPEPTIDE-2 should be stored long-term in a freezer between -20°C and -15°C, protected from light, within an air-proofed container. Under these conditions, it maintains stability for up to 24 months.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Moderate

While generally considered a safe ingredient without commonly reported serious side effects, individuals with a predisposition to dermatological sensitivities may experience allergic reactions, necessitating a patch test. Critically, peptides that mimic growth factors, including recombinant IGF-1 (sh-Oligopeptide-2), have been correlated with tumorigenesis or progression, and specifically recombinant IGF-1 has been linked to melanoma progression. Therefore, its use requires careful consideration and professional guidance.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Questionable

While offering significant benefits for skin regeneration and anti-aging through its growth factor-mimicking action, the correlation of IGF-1 with tumorigenesis progression necessitates extreme caution and a thorough risk-benefit assessment.

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