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TRANS-3-METHYL-5-PHENYL-2-PENTENENITRILE.

Optional CAS 53243-60-0 / PERFUMING

TRANS-3-METHYL-5-PHENYL-2-PENTENENITRILE functions primarily as a sophisticated fragrance ingredient, imparting a diverse spectrum of citrus, fruity, floral (rose), and spicy notes to cosmetic formulations. Its role is to enhance and extend the aromatic profile of products, particularly within woody-floral and amber accords.

fragrance

Science

This compound acts as a multifaceted fragrance enhancer, engaging the olfactory system to deliver a complex sensory experience. It contributes distinct scent notes including citrusy, fruity, rose-like, cinnamon, green, spicy, and balsamic facets. Its precise molecular structure allows it to modify and provide a long-lasting lift to various fragrance compositions, without exhibiting any known direct biochemical mechanisms on skin physiology.


Research

Low confidence
Effective range N/A
Optimal

N/A


Transparency

Commonly dusted
Red flag below
0.0097%

As a component exclusively dedicated to fragrance without inherent skincare benefits, its inclusion in formulations can be considered 'dusting' if its concentration exceeds the minimal required for sensory impact, particularly given its sensitization potential. A concentration above 0.0097% in a leave-on skincare product without a primary fragrance claim warrants careful scrutiny.


The Formula

Solubility
Oil
Optimal pH 2 – 10
0 7 14

Stability

This ingredient exhibits robust stability across a broad pH spectrum, maintaining integrity in highly acidic conditions (pH 2, very good) and alkaline environments (pH 9-10, good), with excellent stability observed at neutral pH (6). It is highly compatible with both alcohol-based and oil-based systems. However, its stability is compromised by strong acids, oxidizers, and bleach, which should be avoided.

Conflicts

  • strong acids
  • oxidizers
  • bleach

Safety

CIR Status
Safe with restrictions
Max tested
0.0097%
Sensitization risk Moderate

Safety assessments by the Research Institute for Fragrance Materials (RIFM) confirm it is not genotoxic, phototoxic, or photoallergenic. However, it presents a potential for skin sensitization in a small proportion of individuals. The International Fragrance Association (IFRA) has established stringent standards to mitigate this risk, dictating a maximum acceptable concentration of 0.0097% for 'Baby cream, oil, talc' (representative of sensitive leave-on cosmetic categories). Higher concentrations, up to 0.12%, may be permissible in other specific cosmetic applications.


Your Skin

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Optional

TRANS-3-METHYL-5-PHENYL-2-PENTENENITRILE is an optional ingredient, valued solely for its complex fragrance profile, but requires precise formulation to remain within strict concentration limits due to its moderate sensitization risk.


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