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TRANS-2-TERT-BUTYLCYCLOHEXANOL.

Insufficient Data CAS 5448-22-6 / PERFUMING

TRANS-2-TERT-BUTYLCYCLOHEXANOL is a chemical compound primarily utilized as a fragrance ingredient, including in soap perfumes. It represents the more stable trans-isomer of 2-tert-butylcyclohexanol, a compound recognized by precisionFDA.

Summary

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

The trans isomer of 2-tert-butylcyclohexanol is inherently more stable than its cis counterpart. This increased stability is attributed to the spatial arrangement of its bulky tert-butyl groups.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) has not assessed TRANS-2-TERT-BUTYLCYCLOHEXANOL. The broader compound, 2-tert-butylcyclohexanol (a mixture of cis- and trans- isomers), is listed by precisionFDA and has been reported to cause serious eye irritation (H319). A RIFM safety assessment for the mixed isomers indicated no concern for genetic toxicity.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

With no identified clinical efficacy data for skin benefits and a reported potential for serious eye irritation, the inclusion of TRANS-2-TERT-BUTYLCYCLOHEXANOL in precision skincare formulations requires further investigation.

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