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TRANEXAMOYL SH-PENTAPEPTIDE-12 SP.

Valuable / SKIN CONDITIONING - MISCELLANEOUS

TRANEXAMOYL SH-PENTAPEPTIDE-12 SP is an innovative cosmetic peptide engineered to address both dynamic wrinkles and hyperpigmentation. It offers a dual-action approach, effectively reducing muscle-induced fine lines while simultaneously brightening the skin and diminishing dark spots for a more uniform complexion.

Summary

Anti-wrinkle Skin brightening Anti-aging Skin conditioning Hyperpigmentation reduction

Science

Mechanism of Action

This advanced ingredient operates through two distinct yet complementary mechanisms. The SH-PENTAPEPTIDE-12 SP component mimics a 'type C botulinum toxin peptide,' working to relax facial muscles by inhibiting neurotransmitter release at the neuromuscular junction. It achieves this by competing for and destabilizing SNARE complexes, thereby reducing acetylcholine release and softening the appearance of wrinkles. Concurrently, the Tranexamoyl moiety targets hyperpigmentation by inhibiting tyrosinase, a key enzyme in melanin synthesis, and reducing the expression of MITF, which regulates melanocyte activity. This combined action leads to diminished melasma, dark spots, and overall skin brightening.

Research

Clinical Evidence

Medium confidence
Effective range 1–10%
Optimal

N/A

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Unknown
Optimal pH N/A
0 7 14

Stability

Related Tranexamoyl peptides, such as Tranexamoyl Dipeptide-23, demonstrate enhanced stability and effectiveness in formulations due to the tranexamic acid (TXA) modification.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Low

While TRANEXAMOYL SH-PENTAPEPTIDE-12 SP has not been reviewed by CIR, SCCS, or FDA, related Tranexamoyl peptides (e.g., Tranexamoyl Dipeptide-23) have shown safety in cytotoxicity studies. The SH-PENTAPEPTIDE-12 SP component is generally considered to have low safety concerns, with 'No penalty' reported across categories by INCI Beauty.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

TRANEXAMOYL SH-PENTAPEPTIDE-12 SP is a valuable multi-functional ingredient, offering targeted action against both dynamic wrinkles and various forms of hyperpigmentation, making it a powerful addition to comprehensive anti-aging and brightening regimens.

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