Science
Mechanism of Action
This synthetic tripeptide (Txa-Val-Ser) operates through a potent dual mechanism to address hyperpigmentation. It directly inhibits the activity of tyrosinase, a key enzyme essential for melanin production. Concurrently, it suppresses the expression of MITF (microphthalmia-associated transcription factor), which governs the differentiation and proliferation of melanin-producing cells (melanocytes). This combined action effectively diminishes the appearance of hyperpigmentation, melasma, and dark spots. Its unique molecular modification also enhances stability within formulations and improves efficacy, while its small size contributes to excellent skin permeability and a high penetration rate, allowing it to potentiate the action of other brightening agents.
Research
Clinical Evidence
Medium confidence0.05%
Transparency
Dusting Analysis
The Formula
Formulation
Stability
The strategic modification of Tranexamic Acid into Tranexamoyl Dipeptide-22 significantly enhances its stability within various cosmetic formulations. It exhibits synergistic effects, working effectively to potentiate other skin-whitening agents, particularly Tranexamic acid and related Tranexamoyl- and Nicotinyl-peptides.
Synergies
- Tranexamic acid
- Tranexamoyl-peptides
- Nicotinyl-peptides
Safety
Safety Profile
Cytotoxicity tests have indicated that Tranexamoyl Dipeptide-22 is a safe ingredient for various skincare applications.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tranexamoyl Dipeptide-22 is a valuable ingredient for precisely targeting hyperpigmentation and enhancing skin brightness, offering a dual mechanism of action, proven efficacy, and broad skin compatibility across all skin types.
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References
Sources