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Moumoujus

TORENIA CONCOLOR EXTRACT.

Valuable / ANTIOXIDANT, SKIN PROTECTING

Torenia Concolor Extract is a botanical active that demonstrates a dual action in skincare: potent anti-inflammatory effects and the ability to regulate lipid metabolism. It achieves these benefits by modulating key cellular pathways, offering a promising approach for targeted skin concerns.

Summary

Anti-inflammatory Lipid Metabolism Regulation Soothing

Science

Mechanism of Action

The extract's anti-inflammatory efficacy is rooted in its ability to suppress the expression of inflammatory mediators, specifically inducible nitric oxide synthase (iNOS) and interleukin-6 (IL-6). This action is mediated via the activation of the peroxisome proliferator-activated receptor gamma (PPARγ) signaling pathway. Furthermore, specific fractions, such as the ethyl acetate and n-butanol extracts, contribute to lipid metabolism regulation by activating peroxisome proliferator-activated receptor alpha (PPARα) and enhancing adiponectin expression, thereby promoting healthy lipid processing and reducing cellular lipid accumulation.

Research

Clinical Evidence

Medium confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 An ethanol extract (TCEE) at 150 µg/ml demonstrated a significant inhibitory effect on nitrite production in RAW264.7 macrophage cells, comparable to the anti-inflammatory drug dexamethasone (DEX). It also notably reduced iNOS and IL-6 protein expression and activated PPARγ protein expression.
  2. 02 An ethyl acetate extract (TCEAE) at 150 µg/ml exhibited significant inhibition of nitrite production, reduced iNOS and IL-6 protein expression, activated PPARγ, promoted adiponectin expression, and increased PPARα protein expression in 3T3-L1 cells, indicating regulation of lipid metabolism.
  3. 03 An n-butanol extract (TCBUE) at 250 µg/ml effectively inhibited nitrite production, reduced iNOS and IL-6 protein expression (though less potently than TCEE/TCEAE), activated PPARγ, promoted adiponectin expression, and increased PPARα protein expression in 3T3-L1 cells.
  4. 04 A water extract (TCWE) at 400 µg/ml displayed an inhibitory effect on nitrite production, albeit less pronounced compared to the other solvent extracts.

Transparency

Dusting Analysis

Not commonly dusted

No data available suggests that Torenia Concolor Extract is commonly 'dusted' or used at concentrations below its effective threshold in formulations.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract comprises components soluble in various solvents, including water, ethanol, ethyl acetate, and n-butanol. While related Torenia species containing anthocyanins may exhibit pH-dependent color changes and increased stability in mildly acidic conditions (e.g., pH 4-8), specific optimal pH for the stability of Torenia Concolor Extract in cosmetic formulations has not been directly documented.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessments by recognized regulatory bodies such as CIR (Cosmetic Ingredient Review), SCCS (Scientific Committee on Consumer Safety), or FDA (Food and Drug Administration) were found for Torenia Concolor Extract. Further safety profiling for topical application is recommended.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Torenia Concolor Extract presents valuable in vitro evidence for its anti-inflammatory and lipid-regulating capabilities, positioning it as a promising active for precision skincare, pending further in vivo efficacy and safety assessments.

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