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Moumoujus

TOCOPHERYL NICOTINATE.

Optional CAS 16676-75-8 / 43119-47-7 / 51898-34-1 / 86362-36-9 / ANTIOXIDANT, SKIN CONDITIONING, SKIN PROTECTING

Tocopheryl Nicotinate is an ester combining Vitamin E (tocopherol) and Vitamin B3 (nicotinic acid). It delivers multifaceted benefits, acting as a potent antioxidant, a microcirculation enhancer, and a supporter of skin barrier integrity.

Summary

antioxidant skin conditioning skin protecting vasodilatory microcirculation enhancer skin barrier support skin brightening soothing

Science

Mechanism of Action

This ingredient functions primarily as a powerful antioxidant, effectively neutralizing free radicals to protect skin cells from oxidative stress and mitigate collagen degradation. Its vasodilatory properties are key to enhancing microcirculation; it expands capillaries, increasing blood flow and oxygenation, which in turn delivers essential nutrients to skin cells, thereby improving cellular metabolism, skin luminosity, and overall resilience. Tocopheryl Nicotinate also strengthens the skin barrier by supporting ceramide synthesis and reducing transepidermal water loss (TEWL), enhancing skin hydration and elasticity. Upon absorption, it is metabolized into Vitamin E within the skin.

Research

Clinical Evidence

Low confidence
Effective range 0.001–0.001%
Optimal

N/A

Key findings

  1. 01 Studies indicate that concentrations ranging from 0.1% to 1% can improve microcirculation and enhance hair growth. However, it is crucial to note that the Cosmetic Ingredient Review (CIR) Expert Panel has set a maximum usage level of 0.001% for leave-on cosmetic formulations, meaning that the full vasodilatory benefits observed at higher concentrations are not achievable within current regulatory limits for such products.

Transparency

Dusting Analysis

Not commonly dusted

No specific information regarding dusting concerns was found in the research data.

The Formula

Formulation

Solubility
Oil
Optimal pH N/A
0 7 14

Stability

This ingredient should be protected from strong oxidizing agents and strong acids. It exhibits a melting point between 36°C and 40°C, becoming a wax-like solid at room temperature, and therefore requires thorough blending before use for proper integration. It is biodegradable.

Conflicts

  • strong oxidizing agents
  • strong acids

Safety

Safety Profile

CIR Status
Safe as used
Max tested
0.001%
Sensitization risk Low

The CIR Expert Panel concluded Tocopheryl Nicotinate is safe for use in cosmetics, with a maximum concentration of 0.001% for leave-on products and 0.1% for rinse-off applications. While generally considered non-irritating, a mild warming sensation or slight irritation may occur at the application site. There is no SCCS information available. It is not an FDA-approved sunscreen active ingredient.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
No Oily
No Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Optional

While offering antioxidant and skin-conditioning benefits, its vasodilatory properties for enhanced microcirculation are likely unachievable in leave-on products due to strict regulatory concentration limits (0.001% CIR max).

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