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TOCOPHERYL DIMETHYLGLYCINATE HCL.

Insufficient Data CAS - / ANTIOXIDANT, SKIN CONDITIONING

TOCOPHERYL DIMETHYLGLYCINATE HCL is a novel, hydrophilic derivative of gamma-tocopherol, a potent form of Vitamin E. It is engineered to deliver antioxidant protection and enhance skin conditioning, making it a valuable asset for overall skin health and resilience.

Summary

Antioxidant Skin Conditioning

Science

Mechanism of Action

This ingredient functions by leveraging its tocopherol component to provide robust antioxidant defense against free radicals, UV radiation, and environmental stressors. The dimethylglycinate portion is theorized to support skin repair processes and healing by potentially aiding in collagen and elastin production, alongside its own free radical neutralizing capabilities, contributing to anti-aging benefits and overall dermal vitality.

Research

Clinical Evidence

Low confidence
Effective range N/A
Optimal

N/A

Key findings

  1. 01 Topical application of a gamma-tocopherol derivative, inclusive of gamma-tocopherol-N,N-dimethylglycine ester, demonstrated a reduction in photo-inflammation, prevention of UV-induced skin pigmentation, and mitigation of UV-induced skin damage.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Stability

The ingredient is described as hydrophilic and water-soluble. However, its raw chemical precursor, N,N-Dimethylglycine (hydrochloride), while soluble in PBS (pH 7.2) at approximately 10 mg/ml, is not recommended for storage in aqueous solutions for more than one day due to potential stability concerns.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

The Cosmetic Ingredient Review (CIR) Expert Panel has assessed the safety of 14 other tocopherols and tocotrienols, concluding them to be 'safe as used in cosmetics'; however, TOCOPHERYL DIMETHYLGLYCINATE HCL was not specifically included in that review. It is noteworthy that the raw chemical N,N-Dimethylglycine (hydrochloride) is classified as an 'Irritant' with hazard statements for skin and eye irritation, though this classification pertains to the raw material and not necessarily to the ingredient when formulated in cosmetic products.

Your Skin

Skin Compatibility

No Normal
No Dry
No Oily
No Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Insufficient Data

While demonstrating promising antioxidant and skin-supportive effects in animal studies, TOCOPHERYL DIMETHYLGLYCINATE HCL requires further human clinical data and specific safety assessments to fully establish its efficacy and safety profile in cosmetic applications.

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