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TINOSPORA CORDIFOLIA STEM EXTRACT.

Valuable CAS 90131-61-6 / SKIN CONDITIONING

Tinospora Cordifolia Stem Extract is a botanical active recognized for its comprehensive dermatological benefits. It demonstrates robust anti-inflammatory, antioxidant, and antimicrobial properties, making it valuable for soothing irritated skin, combating oxidative stress, and supporting overall skin health. Its wound healing capabilities further enhance its utility in precision skincare formulations.

Summary

Skin Conditioning Anti-inflammatory Antioxidant Antimicrobial Wound Healing Immunomodulatory

Science

Mechanism of Action

This extract operates through multiple pathways to enhance skin health. It modulates inflammatory responses by reducing inflammation and fostering epidermal regeneration. Its inherent antimicrobial activity targets common skin pathogens like Pseudomonas spp., Proteus spp., and E. coli, which can contribute to infections and acne. Furthermore, the presence of potent phytochemicals, including phenols and flavonoids, confers significant antioxidant capacity, effectively neutralizing free radicals and mitigating oxidative damage. The extract also exhibits immunomodulatory and anti-allergic effects, contributing to a strengthened skin barrier and reduced reactivity.

Research

Clinical Evidence

Medium confidence
Effective range 5–10%
Optimal

5%

Key findings

  1. 01 Topical application of 5% and 10% gel formulations significantly enhanced wound healing and reduced inflammation in albino rabbits, with the 5% concentration also showing negligible irritancy.
  2. 02 In vitro, the extract exhibited dose-dependent antioxidant activity, inhibiting deoxyribose degradation by 41.5% at 100 ppm and 64.7% at 200 ppm.
  3. 03 An in vitro study determined a minimum inhibitory concentration (MIC) of 1024 µg/mL against Pseudomonas aeruginosa, indicating antibacterial efficacy.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Water
Optimal pH N/A
0 7 14

Safety

Safety Profile

CIR Status
Not reviewed
Max tested
10%
Sensitization risk Low

Topical gel formulations at 5% and 10% concentrations demonstrated negligible irritant properties in studies conducted on albino rabbits, suggesting a favorable safety profile for cosmetic application.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Low
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Tinospora Cordifolia Stem Extract is a valuable botanical ingredient, offering a synergistic blend of anti-inflammatory, antioxidant, and antimicrobial actions, alongside wound healing support, making it beneficial for diverse skin concerns.

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