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Moumoujus

TINOSPORA CORDIFOLIA EXTRACT.

Valuable CAS 90131-61-6 / SKIN CONDITIONING

Tinospora Cordifolia Extract is a multi-functional botanical ingredient celebrated for its potent anti-inflammatory, antioxidant, and immunomodulatory effects. It actively supports skin regeneration and repair, addressing various skin concerns for enhanced epidermal health.

Summary

Anti-inflammatory Antioxidant Immunomodulatory Wound Healing Antibacterial Collagen Boosting Pore Minimizing Elasticity Enhancing

Science

Mechanism of Action

This extract functions as a robust anti-inflammatory agent, mitigating adverse immune responses and oxidative stress by scavenging free radicals. It exhibits immunomodulatory properties by influencing cellular activity, specifically reducing Th17 cell frequency and promoting CD4+ T cell proliferation. On the skin, it accelerates wound healing through enhanced re-epithelialization, improved blood vessel formation, and increased collagen deposition, while also providing antibacterial capabilities and potentially improving skin elasticity and reducing pore appearance.

Research

Clinical Evidence

Medium confidence
Effective range 500–2000%
Optimal

N/A

Key findings

  1. 01 In vitro studies have demonstrated that Tinospora Cordifolia Extract, at concentrations ranging from 500-2000 µg/ml, effectively reduced Th17 cell frequency and inhibited CD4+ T cell proliferation, maintaining non-cytotoxicity below 1500 µg/ml.
  2. 02 Animal model research indicates significant enhancement of wound healing, characterized by reduced inflammation, restoration of typical blood vessels and collagen fibers, and swift epidermal closure.
  3. 03 Further studies in a mouse skin wound model confirmed its antibacterial and anti-inflammatory properties.

Transparency

Dusting Analysis

Not commonly dusted

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

The extract's solubility, penetration, and stability can be significantly enhanced through encapsulation in water-in-oil nanoemulsions. Surfactant concentration is a critical variable influencing the stability of these nanoemulsions.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No formal GHS classification as hazardous was found in reviewed safety information. Dermal and oral/parenteral toxicity assessments have been reported as 'not determined' in some sources.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Tinospora Cordifolia Extract is a valuable ingredient for advanced skincare formulations, providing comprehensive benefits for reducing inflammation, combating oxidative stress, and promoting skin repair across all skin types.

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