Science
Mechanism of Action
This extract functions as a potent antioxidant, safeguarding cellular structures from free radical damage, a property linked to its abundant polyphenol, flavonoid, and chlorophyll content. Its anti-inflammatory capabilities may stem from the inhibition of cyclooxygenase (COX) enzymes. For skin, it uniquely stimulates the proliferation of fibroblasts and keratinocytes, upregulates collagen expression, and counteracts collagenase activity, thereby mitigating visible signs of aging such as fine lines, wrinkles, and loss of firmness. Additionally, it enhances cell-cell adhesion within both the epidermis and dermis, optimizes nutrient delivery to the epidermis, and reinforces dermal-epidermal junctions, collectively contributing to improved skin firmness, plumpness, suppleness, and refined texture.
Research
Clinical Evidence
Medium confidenceN/A
Transparency
Dusting Analysis
The Formula
Formulation
Stability
Optimal stability is achieved by avoiding boiling or simmering during aqueous extraction methods, as water extraction is specifically noted for effectively preserving bioactive integrity and ensuring high phenolic content. The extract can be incorporated into a wide range of formulations including aqueous, alcohol-based, or aqueous/alcohol-based solutions, various emulsion types (water-in-oil, oil-in-water, water-oil-water triple emulsions, microemulsions), as well as ointments, lotions, gels, and aerosols.
Safety
Safety Profile
No specific Cosmetic Ingredient Review (CIR) or SCCS assessment for cosmetic use is available. However, Tiliacora Triandra Leaf/Vine Extract is generally considered non-irritating when applied topically. For oral consumption, animal studies indicated no adverse effects on hematological or blood biochemical parameters at doses up to 2,000 mg/kg. It is also processed under FDA standards when used as a food ingredient. It is important to note that in vitro studies revealed cytotoxicity against HeLa cells at 0.41 mg/ml (equivalent to 410 µg/ml) and lymphocytes at 10 mg/ml (10,000 µg/ml). While these cytotoxic concentrations are significantly higher than the effective antioxidant IC50s (e.g., ~180 µg/ml), careful consideration of concentration is advised during formulation to ensure optimal safety and efficacy.
Your Skin
Skin Compatibility
Our Assessment
Verdict
Tiliacora Triandra Leaf/Vine Extract is a valuable botanical ingredient, offering comprehensive benefits for skin vitality through its potent antioxidant, anti-inflammatory, and regenerative properties, making it an excellent candidate for advanced anti-aging and skin health formulations.
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