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Moumoujus

TIARELLA POLYPHYLLA EXTRACT.

Valuable / SKIN CONDITIONING, SKIN PROTECTING

Tiarella Polyphylla Extract is a botanical active demonstrated to combat signs of photoaging and protect skin cells from UVB-induced damage. It actively supports skin's structural integrity by promoting collagen production and inhibiting enzymatic degradation, while also offering antioxidant and potential brightening benefits.

Summary

Anti-aging Photoprotective Collagen Support Antioxidant Skin Brightening Anti-inflammatory Sebum Regulation

Science

Mechanism of Action

This extract operates by targeting key mechanisms of skin aging and photodamage. It significantly suppresses matrix metalloproteinase (MMP) activity, specifically MMP-1, MMP-2, and MMP-3, which are enzymes responsible for breaking down collagen and elastin. Concurrently, it boosts the levels of type I procollagen, a precursor to vital collagen types (COL-1 and COL-3), thereby enhancing skin's firmness and elasticity. The extract also demonstrates inhibition of lipoxygenase and tyrosinase, alongside providing antioxidative protection, contributing to a more even tone and reduced oxidative stress.

Research

Clinical Evidence

Medium confidence
Effective range 0.01–0.025%
Optimal

N/A

Key findings

  1. 01 In human foreskin fibroblasts (Hs68 cells), this concentration effectively inhibited UVB-induced cellular damage, reduced MMP-1 levels, and increased type I procollagen. It also prevented UVB-mediated degradation of COL-1 and COL-3 proteins and the overexpression of MMP-1, MMP-2, and MMP-3, indicating significant anti-aging and photoprotective effects.
  2. 02 Consistent with lower concentrations, a 0.025% concentration in Hs68 cells similarly inhibited UVB-induced cell damage, suppressed MMP-1, and elevated type I procollagen levels. It also effectively mitigated UVB-mediated degradation of COL-1 and COL-3 and the overexpression of MMP-1, MMP-2, and MMP-3, confirming robust anti-aging and photoprotective capabilities.

Transparency

Dusting Analysis

Not commonly dusted

Information regarding the common practice of 'dusting' this ingredient or specific concentration thresholds for minimal efficacy is not available in the provided research data.

The Formula

Formulation

Solubility
Both
Optimal pH N/A
0 7 14

Stability

Tiarella Polyphylla Extract components exhibit both water and oil solubility, allowing extraction with various solvents including water, alcohols, glycols, and oils. While general plant extracts often show stability at neutral (pH 7) and alkaline (pH 9) conditions, specific optimal pH ranges for the stability of this extract in cosmetic formulations are not explicitly detailed.

Safety

Safety Profile

CIR Status
Not reviewed
Sensitization risk Unknown

No specific safety assessment by regulatory bodies such as the Cosmetic Ingredient Review (CIR) or the Scientific Committee on Consumer Safety (SCCS) has been conducted for Tiarella Polyphylla Extract. Furthermore, no FDA 'Generally Recognized As Safe' (GRAS) status for its cosmetic use has been identified. Therefore, comprehensive safety profiles, including maximum safe concentrations or detailed irritancy/sensitization data, are not yet established.

Your Skin

Skin Compatibility

Yes Normal
Yes Dry
Yes Oily
Yes Sensitive
Irritancy Unknown
Comedogenicity Unknown

Our Assessment

Verdict

Valuable

Tiarella Polyphylla Extract presents compelling in-vitro evidence for its anti-aging, photoprotective, and collagen-boosting capabilities at concentrations between 0.01% and 0.025%, making it a valuable active despite pending comprehensive safety reviews.

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